MAINTENANCE of myocardial viability is one of the major considerations during direct operations on the aortic valve. Our preference is to cannulate the coronary ostia and perfuse the myocardium with 300 ml. of blood per minute at a temperature of 30 C. Others' report satisfactory results with cardiac hypothermia and anoxic arrest. It is our habit to have iced Ringer's solution available so that...

Hypothermia is defined as a core body temperature of <95°F (<35°C) and is caused by environmental exposure, drug intoxication, or metabolic or nervous system dysfunction. Exposure to cold is a leading cause of weather-related mortality and is responsible for approximately twice the number of deaths annually as exposure to heat in the United States. To understand the risk factors for hypothermia...

base state of vertebrates. Fed Proc 28: 1204-1208, 1969 29. Hagerdal M, Harp JR, Siesjo BK: Influence of changes in 32. arterial Pco2 on cerebral blood flow and cerebral energy state during hypothermia in the rat. Acta Anaesth Scand Suppl 47: 33, 25-33, 1975 30. Blair E, Montgomery AV, Swan H: Post-hypothermic cir34. culatory failure. I. Physiologic observations on the circulation. Circ 13: 909...

OBJECTIVES To investigate the effects of local mild hypothermia on the expression of Fas, FasL and MMP-3 after cerebral ischemia-reperfusion in rats. MATERIALS AND METHODS Male Wistar rats were divided into sham-operated group (Sham), normothermia group (NT), and hypothermia group (HT). MCAO/R model was established by Longa's method, and reperfusion was allowed after 2 hr occlusion. Mild hypo...

OBJECTIVE The neuroprotective effect of hypothermia has long been recognized. Use of hypothermia for stroke therapy, which is currently being induced by whole-body surface cooling, has been limited primarily because of management problems and severe side effects (e.g., pneumonia). The goal of this study was to determine whether local infusion of saline into ischemic territory could induce regio...

Article type: Original article Objective(s): To investigate the effects of local mild hypothermia on the expression of Fas, FasL and MMP-3 after cerebral ischemia-reperfusion in rats. Materials and Methods: Male Wistar rats were divided into sham-operated group (Sham), normothermia group (NT), and hypothermia group (HT). MCAO/R model was established by Longa’s method, and reperfusion was allowe...

BACKGROUND In the oligofructose (OF) model of sepsis-related laminitis (SRL), digital hypothermia ("cryotherapy") initiated before the onset of clinical signs is reported not only to limit lamellar injury, but also to cause marked inhibition of lamellar inflammatory signaling. HYPOTHESIS/OBJECTIVES Because hypothermia also has been reported to be protective when not initiated until the onset ...