The dynamics of a general in-host model with intracellular delay is studied. The model can describe in vivo infections of HIV-I, HCV, and HBV. It can also be considered as a model for HTLV-I infection. We derive the basic reproduction number R0 for the viral infection, and establish that the global dynamics are completely determined by the values of R0. If R0 < or = 1, the infection-free equili...

An SEI model with distributed delay is proposed where the transmission and the death rates depend on the age of infection. The basic reproduction number R0 is identified as a threshold quantity for the stability of equilibria. If R0 < 1, then the disease-free equilibrium is globally asymptotically stable and the disease dies out. On the contrary, ifR0 > 1, then a locally asymptotically stable e...

In this paper, an ordinary differential equation model of HIV infection of CD4 T-cells with saturated reverse function is studied. We prove that if the basic reproduction number R0 < 1, the virus-free equilibrium is locally asymptotically stable. And there will exhibit backward bifurcation when R0 < 1. If R0 > 1, some feasibly sufficient conditions are obtained for the global asymptotic stabili...

Stability of differential inclusions defined by locally Lipschitz compact valued maps is addressed. It is shown that if such a differential inclusion is globally asymptotically stable, then in fact it is uniformly globally asymptotically stable (with respect to initial states in compacts). This statement is trivial for differential equations, but here we provide the extension to compact (not ne...

In this paper, a model for the use of heroin with treat-age is formulated based on the principles of mathematical epidemiology. The model accounts for relapse rate that depends on how long the host has been in treatment for heroin addiction. An explicit formula for the reproductive number of the heroin spread is obtained. By using the method of Lyapunov functional, we established the dynamical ...

An epidemic model with relapse and spatial diffusion is studied. Such a model is appropriate for tuberculosis, including bovine tuberculosis in cattle and wildlife, and for herpes. By using the linearized method, the local stability of each of feasible steady states to this model is investigated. It is proven that if the basic reproduction number is less than unity, the diseasefree steady state...

We formulate a homogeneous model and a stage-structured model for the interactive wild mosquitoes and mosquitoes carrying genetically-modified bacteria. We establish conditions for the existence and stability of fixed points for both models. We show that a unique positive fixed point exists and is asymptotically stable if the two boundary fixed points are both unstable. The unique positive fixe...

This paper presents a novel mathematical model with multidrug-resistant MDR and undetected TB cases. The theoretical analysis indicates that the disease-free equilibrium is globally asymptotically stable if R0 < 1; otherwise, the system may exist a locally asymptotically stable endemic equilibrium. The model is also used to simulate and predict TB epidemic in Guangdong. The results imply that o...

A new SEIR model with distributed infinite delay is derived when the infectivity depends on the age of infection. The basic reproduction number R0, which is a threshold quantity for the stability of equilibria, is calculated. If R0 < 1, then the disease-free equilibrium is globally asymptotically stable and this is the only equilibrium. On the contrary, if R0 > 1, then an endemic equilibrium ap...