OBJECTIVE to report patterns of failure according to treatment modality, with an emphasis on the role of postoperative radiotherapy in patients with localized head and neck mucosal melanoma (HNMM) treated during a 28-year period in a multi-institutional setting. DESIGN retrospective review. SETTING french medical institutions. PATIENTS a total of 160 patients with nonmetastatic HNMM treat...

Clinicopathologic features of esophageal neuroendocrine carcinoma (NEC), apart from those of small-cell carcinoma, have not been characterized. We evaluated the clinicopathologic features and prognosis including overall survival of NEC of the esophagus. We identified 40 patients with esophageal NEC from our institutional database. All cancers had been clinically staged using endoscopic ultrason...

BACKGROUND This study identified sex differences in progression of cutaneous melanoma. METHODOLOGY/PRINCIPAL FINDINGS Of 7,338 patients who were diagnosed as an invasive primary CM without clinically detectable metastases from 1976 to 2008 at the University of Tuebingen in Germany, 1,078 developed subsequent metastases during follow up. The metastatic pathways were defined in these patients a...

BACKGROUND The development of intensity-modulated radiotherapy (IMRT) has revolutionized the management of nasopharyngeal carcinoma (NPC). The purpose of this study was to evaluate the prognostic value and classification of TNM stage system for retropharyngeal lymph node (RLN) metastasis in NPC in the IMRT era. MATERIAL AND METHODS We retrospectively reviewed data from 749 patients with biops...

BACKGROUND The association between expression of cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), and the long-term outcomes in treated nasopharyngeal carcinoma (NPC) was studied. METHODS Expression of COX-2, VEGF, and EGFR by immunohistochemical (IHC) staining was assessed in 128 patients with NPC. Overall survival (OS), disease-fr...

BACKGROUND Despite advances in radiation therapy, chemotherapy, and newly developed molecular targeting therapies, long-term survival after resection for patients with NSCLC remains less than 50%. We investigated factors predicting postoperative locoregional recurrences and distant metastases in patients with clinical stage I non-small-cell lung cancer (NSCLC) after surgical resection. METHOD...

Carcinoma of the gallbladder is considered a disease with grim prognosis owing to frequent locoregional recurrence despite surgery and poor disease specific and overall survival. It can spread directly, transperitoneally as well as via lymphatics, vessels and nerves. Distant spread to almost every organ is described and indicates a very late stage in the course of disease. Hence, evaluation for...

Adenoid cystic carcinoma (ACC) is a malignancy of the secretory epithelial cells salivary glands and constitutes less than 1% all head neck tumors. Metastasis occurs frequently most commonly affects lungs at rate 35 to 50%. In this case report, we present rare nasopharyngeal ACC with distant metastasis liver. Our patient initially presented hospital dental sinus pain initial imaging suggesting ...

OBJECTIVE To investigate the characteristics of recurrences that occurred 5 or more years after curative resection for gastric cancer. METHODS We analyzed recurrences among 1,299 patients with gastric cancer who underwent curative operations at the Department of Surgery, Inje University Seoul Paik Hospital between September 1998 and December 2002. Recurrences were classified as within 2 years...

Abstract Background Induction chemotherapy (ICT) augmentation is a common strategy for standard concurrent chemoradiotherapy (CCRT) of locoregionally advanced nasopharyngeal carcinoma (NPC). The survival condition crucial issue patients with NPC. ICT CCRT treatment versus alone should be elucidated via systemic review and meta‐analysis randomized clinical trials. Methods We compared to determin...