To investigate the pharmacokinetics and pharmacodynamics of Astragali Radix-Corni Fructus herb-pair in kidney-yin deficiency model, which was made by continuously oral gavage thyroxine. A simple rapid LC-MS/MS method developed validated for determination loganin morroniside rat plasma used study. The significantly changed AUC(0-∞), Cmax CLz/F morroniside. T1/2z increased rats. For study, liver ...

Traditional medicines are being focused on as possible treatments for diabetes and its complications because of their negligible toxic and/or side effects. In line with this, our group has reported that Corni Fructus, a traditional medicine considered exhibiting beneficial effects on liver and kidney functions, possessed an antidiabetic effect via ameliorating glucose-mediated metabolic disorde...

Alstonia boonei De Wild is a herbal medicinal plant of West African origin, popularly known as God's tree or "Onyame dua". Within West Africa, it is considered as sacred in some forest communities; consequently the plant parts are not eaten. The plant parts have been traditionally used for its antimalarial, aphrodisiac, antidiabetic, antimicrobial, and antipyretic activities, which have also be...


 Purpose: To study the pharmacokinetics of morroniside (MR) and loganin (LG) in rats after oral administration raw wine-processed Corni fructus by UPLC-QqQ-MS/MS.
 Methods: Arctiin (AT) was used as internal standard, plasma or tissue samples were extracted twice using ethyl acetate. Electrospray ionization (ESI) negative ion mode used, multiple reaction monitoring (MRM) set acquisiti...

Allergy-preventive activity of flower buds of Lonicera japonica THUNB. was found in the 35% EtOH extract (LJ) using an in vivo assay, The assay system uses monitoring of a decrease in blood flow (BF) in the tail vein of mice subjected to sensitization with hen-egg white lysozyme (HEL). Bioassay-guided fractionation of the 35% EtOH extract led to isolation of chlorogenic acid (1) and three known...

Fresh first year roots from Dipsacus sylvestris HUDS. were extracted with 70% ethanol, ethyl acetate as well as dichloromethane. Extracts were solubilized in water (lipophilic extracts with addition of polysorbate 80) and tested for their activity against Borrelia burgdorferi sensu stricto in vitro during an eight-day period using amoxicillin as standard. The hydroethanolic extract showed no gr...