A novel antisense oligonucleotide (ASO) carrier, polyethylenimine conjugated to linoleic acid (PEI-LA), was synthesized and evaluated for delivery of LOR-2501 to tumor cells. LOR-2501 is an ASO targeting ribonucleotide reductase R1 subunit (RRM1). In this study, PEI-LA was synthesized by reacting PEI (Mw ~ 800) with linoleoyl chloride. Gel retardation assay showed complete complexation between ...

The Japanese mugwort, Artemisia princeps (yomogi in Japanese), has anti-inflammatory and antioxidant effects. Skin care products containing Artemisia princeps extract (APE) are known to improve dry skin symptoms in atopic dermatitis. Atopic dry skin is associated with a marked reduction of skin barrier proteins, such as filaggrin (FLG) and loricrin (LOR). Recently, aryl hydrocarbon receptor (AH...

Avidity for behaviors mediated by nondrug rewards, such as novelty seeking or intake of sweets or fats, is predictive of enhanced vulnerability to the locomotor-activating and rewarding effects of drugs of abuse. The purpose of the present study was to determine whether avidity for wheel running was predictive of subsequent cocaine-induced locomotor activity, cocaine self-administration, and co...

OBJECTIVE A significant proportion of patients with initial response to Inflximab (IFX), subsequently lose response (LOR). Multicentre paediatric studies report LOR in 33% to 50% with 3-5year follow-up. Our retrospective study examined durability of response and predictors of LOR. METHODS From our IBD database of 185 children with CD, 65 received IFX maintenance therapy for luminal or fistuli...

Bi-layer lift-off metallization techniques offer significant advantages in resolution, removal, process simplicity, undercut control and yield over conventional single-layer lift-off processes. Because of its ease of application, long shelf life and lower tool cost, the polydimethylglutarimide (PMGI) bi-layer process has become an attractive method for the metallization of III-V compound semico...

This paper presents a simple empirical approach to modeling and forecasting market option prices using localized option regressions (LOR). LOR projects market option prices over localized regions of their state space and is robust to assumptions regarding the underlying asset dynamics (e.g. log-normality) and volatility structure. Our empirical study using three years of daily S&P500 options sh...

A technique determines the optimal window width for orbiting rod transmission studies in positron emission tomography (PET). Windowing reduces noise in orbiting rod transmission studies. Lines-of-response (LOR) which intersect the rods generate primarily true coincidence events. LOR which pass far from the rods generate random and scatter events. Since the angular position of the orbiting rods ...

In December 1907, Minkowski expressed the Maxwell equations in the very beautiful and compact 4dimensional form: lor f = −s, lor F ∗ = 0. Here ‘lor’, an abbreviation of Lorentz, represents the 4dimensional differential operator. We study Minkowski’s derivation and show how these equations generalize to their modern premetric form in the framework of tensor and exterior calculus. After mentionin...

Domain-specific Internet of Things (IoT) applications are becoming more and more popular. They process data coming from sensor measurements. Adding semantic annotations to the sensory observations and measurements can allow to reason on data via logical rules. Stemming from Linked Open Data and Linked Open Vocabularies, we have designed sensor-based Linked Open Rules (S-LOR). S-LOR allows explo...

A nonlinear recursive filter for the suppression of impulsive noises is proposed. This filter selects from each window a sample closest in value to the most recent output, and is thus named the lust output reference (LOR) filter. A relationship between the LOR and recursive median filters is derived, and some statistical properties are studied through computer simulations. The results indicate ...