Development and validation of an analytical UV derivative spectrophotometric method to quantify Losartan potassium used as a single active principle in pharmaceutical forms were done. Pharmacopeias have not yet provided an official method for its quantification. A study was carried out of all the parameters established by USP XXIV to validate an analytical method for a solid pharmaceutical form...

Abstract: Background: Natural biopolymers or hydrogels that are biodegradable and safe from biological point of view along with their capability to retain active principle within network thus prolonging the release. The present work was undertaken explore potential mucilage mature seeds Chia (Salvia hispanica) sustain release water-soluble drugs. Losartan potassium used as a model prepare gelis...

The bioequivalence of two different tablet formulations containing losartan potassium 100 mg was determined in healthy volunteers after a single oral dose in a randomized crossover study. Test and reference products were administered to 60 volunteers with 240 ml water after overnight fasting. Plasma concentrations of losartan and its active carboxylic acid metabolite were monitored over a perio...

OBJECTIVE Metabolic factors such as glycemic control, hyperlipidemia, and hyperkalemia are important considerations in the treatment of patients with type 2 diabetes and nephropathy. In the RENAAL (Reduction of End Points in Type 2 Diabetes With the Angiotensin II Antagonist Losartan) study, losartan reduced renal outcomes in the patient population. This post hoc analysis of the RENAAL study re...

PURPOSE A validated ultra performance liquid chromatography (UPLC) method has been developed and validated for the simultaneous determination of losartan potassium and chlorthalidone in pharmaceutical preparations. METHODS Waters-Acquity UPLC system equipped with Auto Sampler, PDA detector and operated with Empower-2 software was used for the present study. Detection was done at wavelength of...

INTRODUCTION Plasma adiponectin level is markedly in-creased among patients on hemodialysis. This investigation aimed to evaluate the relationship between renin-angiotensin system blockade and serum adiponectin concentration in nondiabetic patients on hemodialysis. MATERIALS AND METHODS This randomized double-blind controlled trial was conducted on a group of nondiabetic patients on regular h...

Simple, rapid and sensitive UV, HPLC and Dissolution methods has been developed and validated for the analysis of Atenolol, Hydrochlorothiazide and Losartan potassium in tablet formulation. Best chromatographic resolution was achieved on a reverse-phase Phenomenex C18 column using acetonitrile: 50mM potassium dihydrogen ortho phosphate (pH 3.5) ratio 50:50 as mobile phase with a flow rate of 1m...

It is not known whether angiotensin II type 1 receptor antagonists can influence the function and morphology of small arteries in renal failure. We investigated the effect of 8-week losartan therapy (20 mg/kg per day) on isolated mesenteric resistance arteries by wire and pressure myographs in 5/6 nephrectomized rats. Plasma urea nitrogen was elevated 1.6-fold after nephrectomy, and ventricular...

The present study aimed to determine the effect of chronic treatment with losartan on transient outward potassium current (Ito) and the expression levels of potassium voltage-gated channel subfamily D members 2 and 3 (Kv4.2 and 3) and voltage-gated potassium channel-interacting protein 2 (KChIP2) in rats. Spontaneously hypertensive (SH) rats and Wistar-Kyoto (WKY) rats were used in the study. T...

Atomic absorption technique is used to determine losartan potassiumthrough the quantitative detection of potassium (K) element in drug.the extraction was carried out by acid digestion and percentagerecovery 97.2%, error percentage -2.8, limit 0.038 μg/ml, relative standard deviation did not exceed 2.58%. The resultswere compared with UV-Visible method 96.5%, 0.93 μg / ml relativestandard more t...