The affinity of low density lipoprotein (LDL) to its receptor is very important, because most of LDL-uptake pathway is done by the LDL receptor and the change in size of LDL particle and the modification in its components may affects the LDL affinity for its receptor. In this study, the effects of lipophilic agents such as vitamin E and seven volatile oils: anethol, eugenol, geraniol, limonene,...

Submit Manuscript | http://medcraveonline.com Abbreviations: NP: Nano Particle; LDL: Low Density Lipoproteins ; HDL: High Density Lipoproteins ; SLDL: Synthetic Low Density Lipoproteins; LDL-Rl: Low Density Lipoprotein Receptor ; SR-Bi: Scavenger Receptor Class B Type I; DTPA: Diethylene Triaminepenta Acetic Acid; SPECT: Single-Photon Emission Computed Tomography; MRI: Magnetic Resonance Imagin...

Submit Manuscript | http://medcraveonline.com Abbreviations: NP: Nano Particle; LDL: Low Density Lipoproteins ; HDL: High Density Lipoproteins ; SLDL: Synthetic Low Density Lipoproteins; LDL-Rl: Low Density Lipoprotein Receptor ; SR-Bi: Scavenger Receptor Class B Type I; DTPA: Diethylene Triaminepenta Acetic Acid; SPECT: Single-Photon Emission Computed Tomography; MRI: Magnetic Resonance Imagin...

Endotoxin induces hyperlipidaemia in experimental animals. In the current study, we investigated whether endotoxin alters hepatic low-density lipoprotein (LDL) receptor expression in rats. Endotoxin treatment suppressed hepatic LDL receptor expression in a dose- and time-dependent manner. Eighteen hours after intraperitoneal injection of increasing amounts of endotoxin, LDL receptor and its mRN...

Very low-density lipoprotein (VLDL) receptor is a member of the low-density lipoprotein (LDL) receptor family. It binds triglyceride rich lipoprotein (TGRL) but not LDL, because it recognizes apolipoprotein (apo)E only but not apoB. The VLDL receptor functions as a peripheral lipoprotein receptor in concert with lipoprotein lipase (LPL) in heart, muscle, adipose tissue and macrophages. In contr...

Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1299 Lipoproteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1299 L...

The low-density lipoprotein receptor (LDLR) is responsible for uptake of cholesterol-carrying lipoprotein particles into cells. The receptor binds lipoprotein particles at the cell surface and releases them in the low-pH environment of the endosome. The focus of the current review is on biochemical and structural studies of the LDLR and its ligands, emphasizing how structural features of the re...

the affinity of low density lipoprotein (ldl) to its receptor is very important, because most of ldl-uptake pathway is done by the ldl receptor and the change in size of ldl particle and the modification in its components may affects the ldl affinity for its receptor. in this study, the effects of lipophilic agents such as vitamin e and seven volatile oils: anethol, eugenol, geraniol, limonene,...

This study examines the kinetic basis for the increment in plasma low density lipoprotein (LDL) levels that accompanies the fenofibrate treatment of severely hypertriglyceridemic (HTG) patients. Seven HTG men with a mean plasma triglyceride level of 1470 mg/dl were treated for 6 weeks. During treatment, their plasma triglyceride level fell by 77% and their cholesterol level by 41%. The fall in ...

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme that plays a key role in regulating the circulating low density lipoprotein cholesterol (LDL-C). Among PCSK9 variants, while gain-of-function mutations aggravate degradation of LDL receptors, leading to familial hypercholesterolemia (FH), whereas loss-of-function increase receptor levels, lower and prevent coronary heart disease...