Introduction: Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and usually fatal lung disease of unknown etiology for which no effective treatments currently exist. In the adults type I and II pneumocytes, forms Components of the alveolar epithelial cells. In this study, we investigated the effect of thalidomide on the alveolar epithelial cells (type I and II pneumocytes) in ...

many studies have been performed for treatment or prevention of pulmonary fibrosis. however, no effective treatment has been found yet. the aim of this study was to investigate the effect of grape seed extract on bleomycin-induced lung fibrosis in rat. hydroalcoholic extract of grape seed (vitis vinifera) was prepared using maceration method. nmri rats weighing 250-300 g were given single intra...

Pulmonary fibrosis is a diverse group of lung disorders defined by varying degrees and inflammation in the pulmonary parenchyma. While it may be caused known disease, e.g., autoimmune or connective tissue disorder, drugs, hypersensitivity to inhaled organic antigens, sarcoidosis, also occurs idiopathic. When we examine pathogenesis fibrosis, see that cellular aging plays major role. Lung fibrob...

gastroesophageal reflux disease (gerd)  is defined with clinical symptoms  of  heart burning and regurgitation. it may be associated with external esophageal symptoms such as chronic cough, asthma, laryngitis, chronic lung disease, sinusitis and pulmonary fibrosis. in the present study, rats with chronic aspiration of gastroduodenal contentswere studied for  cellular phenotypes  and  cytokine c...

the technique of transbronchial lung biopsy (tblb) has expanded the diagnostic yield of bronchoscopy . in this article we are presenting 54 patients with diffuse pulmonary parenchymal involvement who underwent this procedure during six years between june 1980 and december 1989. the diagnostic yield of this technique in diffuse pulmonary parenchymal disease is great and was 66 percent excluding ...

Organizing Lobar Pneumonia is a rare form of Bronchiolitis Obliterans Organizing Pneumonia.  Herein, we report a rare case of organizing pneumonia involving lung, mediastinum and esophagus.  A 16-year-old girl was referred to our center with clinical signs and symptoms of dysphagia and weight loss.  The main abnormal radiologic and endoscopic findings were stricture of the lower third of esopha...

this paper presents four cases of abnormal soft tissue activity in the bone scan of patients with different lesions (lung inflammatory pseudotumor, pulmonary fibrosis, pulmonary metastatic osteosarcoma and metastatic hepatic carcinoma of colon).

idiopathic pulmonary fibrosis (ipf) is a chronic lung disease of unknown etiology. recent investigations have demonstrated that the impaired immune response is a common characteristic feature of ipf. unfortunately, no definitive and effective drug treatment is available that could improve or at least inhibit the progressive course of this fatal disease. that is why one of the main priorities of...

pulmonary fibrosis is a progressive disease of the lungs, which leads to death in human. it has been suggested that transforming growth factor beta 1 (tgf-β1) together with oxidative stress play a central role in the pathogenesis of the ailment. the objective of this study was to evaluate the possible curative effects of black radish, raphanus sativus l . var niger (rsn) on bleomycine (blm) -in...

cystic fibrosis (cf) is an inherited disease that affects multiple organ systems. it is the most common cause of severe progressive lung disease and exocrine panceratic insufficiency. in our investigation 67 patients had cf. of these, 79% had panceratic insufficiency and 92% had lung disease under 2 years age. also 67% of patients were < 2 percentile and 28% between 3-10 percentile weight for a...