The present study investigated antioxidant status in lavage fluid, lung, liver, heart and kidney in a rat model to simulate an inhalation injury as might be encountered by firefighters and burn victims. Anesthetized rats received either a 20% total body surface area (TBSA) full thickness scald or a sham burn. After a 5 h recovery period, half of the animals in the burn or sham burn groups were ...

Objectives. The peroxisome proliferator-activated receptor gamma (PPARγ) pathway exerts anti-inflammatory effects in response to injury. Maraviroc has been shown to have potent anti-inflammatory effects. The aim of this study was to investigate whether PPARγ plays an important role in maraviroc-mediated lung protection following trauma-hemorrhage. Methods. Male Sprague-Dawley rats underwent tra...

Tumor necrosis factor (TNF-α) and nitric oxide (NO) are important vasoactive mediators of septic shock. This study used a well-characterized quantitative permeation method to examine the effect of TNF-α and NO on systemic vascular barrier function in vivo, without confounding endotoxemia, hypotension, or organ damage. Our results showed 1) TNF-α reversibly increased albumin permeation in the sy...

OBJECTIVE This study aimed to investigate whether propofol pretreatment can protect against liver transplantation-induced acute lung injury (ALI) and to explore whether Nrf2 pathway is involved in the protections provided by propofol pretreatment. METHOD Adult male Sprague-Dawley rats were divided into five groups based on the random number table. Lung pathology was observed by optical micros...

abstract- to investigate the effect of draught stress on water relations, stomatal density, chlorophyll content and yield of rapeseed, an experiment was done with four levels of drought stress including l1 (field capacity, fc), l2 (70% available water content, awc), l3 (50% awc), and l4 (30% awc), within three growth stages- including stem elongation (t1), onset of flowering (t2) and silique fo...

Background: A new treatment approach for most patients who have undergone early stage non-small-cell lung carcinoma (NSCLC), is wedge resection plus permanent implant brachytherapy. However, the specification of dose to medium at low energies especially in heterogeneous lung is unclear yet.Objective: The present study aims to modify source strength for different configurations of 125I and 103...

N-acetylcysteine (NAC) has been employed in the treatment of acute lung injury but its therapeutic value is as yet unproven. In the present study we examined the effect of both L- and D-forms of NAC as inhibitors of bleomycin-induced fibrosis in mice. We hypothesized that, because of the D-form is not metabolized, it may be more effective than the L-form in ameliorating lung injury and fibrosis...

the effect of theophylline on colony stimulating factor production by the lung tissue was investigated. addition of various concentrations of theophylline to the lung conditioned medium enhanced csf production at 10 µg/ml and at higher concentrations showed an inhibitory effect. determination of the phosphate content of the medium showed a decrease at 1-3 hours of incubation. addition of amp to...

We studied the effect of 10 cm H2O of continuous positive airway pressure breathing (CPAPB) on steady state lung fluid balance. In 9 of 20 chronically instrumented, unanesthetized sheep, we measured lung lymph flow, pulmonary vascular pressure, cardiac output, pleura! pressure, and lymph and plasma protein concentration during a 2-hour baseline period and 3-4 hours of CPAPB. In eight sheep, we ...

T he importance of the balance of lung fluid and pulmonary edema in experimental and clinical medicine explains the effort made in the last 30 years to measure lung water content and to develop clinically applicable methods. Pulmonary edema is an essential component ofthe spectrum oflung reactions to injury. As defined by the Starling equation,’ damage to the endothelium increases the permeabil...