BACKGROUND The purpose of this study is to determine if the three-step Luria test is useful for differentiating between cognitive disorders. METHODS A retrospective record review of performance on the three-step Luria test was conducted on 383 participants from a university-based dementia clinic. The participants ranged in their diagnosis from frontotemporal dementia (FTD; n = 43), Alzheimer ...

Do mutations arise randomly over time?Or are they induced by unfavorable environments? By addressing these crucial evolutionary questions, Salvador Luria andMaxDelbrückwon a Nobel Prize and helped to start the field of bacterial genetics. In 1943, it had long been known that bacterial cultures rapidly develop resistance to viral infection. Some biologists argued that viruses directly induced re...

The estimation of mutation rates and relative fitnesses in fluctuation analysis is based on the unrealistic hypothesis that the single-cell times to division are exponentially distributed. Using the classical Luria-Delbrück distribution outside its modelling hypotheses induces an important bias on the estimation of the relative fitness. The model is extended here to any division time distributi...