Perfluorinated compounds (PFCs) such as perfluorooctanesulfonate (PFOS) are stable chemicals that accumulate in biological matrix. Toxicity of these compounds including immunotoxicity has been demonstrated in experimental models and wildlife. Although limited number of studies examined the effects of PFOS on human lymphocytes but so far no research has investigated the complete mechanisms of PF...

The immune system of 90-day old piglets SM-1 Novosibirsk breed depends on sex and stress-reactivity. Stress-reactivity was measured using halothane test. immunologic testing performed 30 days after weaning. Our results show that overall piglet demonstrated high proliferative activity T- B- immunocompetent cells with active formation mature T-and B-lymphocytes did not signs immunosuppression. Co...

glycoconjugates and their programmed changes during the course of development in the cell-surface as well as in the extracellular matrix, are known to affect cell differentiation, cellular interaction and other developmental phenomena during embryogenesis. the purpose of this study was to localize n-acetylgalactosamin as well as fucose-containing glycoconjugates in situ during thymus developmen...

background: because of high morbidity of the brucellosis in humans and the potential use of the microorganism as an agent of biologic warfare, protection of effective vaccines and specific diagnostic reagents become necessary to eradicate brucellosis. objective: in this study we aimed to investigate the cytokine responses and changes in peripheral blood lymphocyte subgroups of acute brucellosis...

background: erythropoietin (epo) was first known as a factor for red blood cell proliferation and differentiation. new studies show the effects of epo on immune system. objective: in this study, the effects of pretreatment with recombinant human erythropoietin (rhuepo) on the anti-human leukocyte antibody (anti-hla) titer were determined. methods: three groups of rats were sensitized with human...

about 25-50% of graves' disease (gd) patients develop thyroid eye diseases, which is associated with inflammatory process and abnormalities in the levels of several cytokines in orbital tissues in gd.  the aim of this study was to determine the th1 and th2 serum cytokines in patients with gd with or without ophthalmopathy. serum  levels of  cytokines  and  autoantibodies  including interferon-g...

Background. Earlier, we found a close canonical correlation between parameters of gas discharge visualization (GDV) and principal neuroendocrine factors adaptation. The purpose this study is to elucidate the relationship GDV immunity parameters. Material research methods. We observed twice 10 women men aged 33-76 years without clinical diagnose. In morning in basal conditions at first registere...

the effects of combined radiotherapy (rt) and chemotherapy in the severity of cytogenetic alterations expressed as micronucleus (mn) in peripheral blood lymphocytes of patients treated for esophageal cancer was evaluated. to do this, blood was obtained from 23 and 15 esophageal cancer patients scheduled for chemo-radiotherapy and rt alone, respectively, before, during, and after treatment. bloo...

background rapid dose assessment using biological dosimetry methods is essential to increase the chance of survival of exposed individuals in radiation accidents. objectives we compared the expression levels of the fdxr and rad51 genes at 6 and 18 mv beam energies in human peripheral blood lymphocytes. the results of our study can be used to analyze radiation energy in biological dosimetry. con...

Perfluorinated compounds (PFCs) such as perfluorooctanesulfonate (PFOS) are stable chemicals that accumulate in biological matrix. Toxicity of these compounds including immunotoxicity has been demonstrated in experimental models and wildlife. Although limited number of studies examined the effects of PFOS on human lymphocytes but so far no research has investigated the complete mechanisms of PF...