An evaluation of the capacity of a lyophilized water extract of borage leaves to delay the lipid oxidation process in dry fermented sausages enriched with ω-3 PUFAs has been performed. 340 ppm of lyophilized extract showed an antioxidant capacity equivalent to 200 ppm of a butylhydroxyanisol (BHA) and butylhydroxytoluene (BHT) mixture. Two batches of dry fermented sausages enriched in ω-3 PUFA ...

Orodispersible tablets, usually prepared using freeze-drying method, are becoming a popular drug formulation for patients who have difficulties swallowing solid dosage forms. The influence of drug solubility and concentration on the physical characteristics of lyophilized tablets composed of mannitol and gelatin was investigated. Phenobarbital and phenobarbital sodium were studied as model drug...

The objective of this experiment is to formulate the tigecycline injection by lyophillization technique for better stability and for long term storage. Lactose monohydrate and lactose sprat dried were used with water for injection and hydrochloric acid into 5 ml tubular vials with pre and post purging nitrogen. The filled vials were loaded into lyophilizer and lyophilized them as per cycle. Dif...

Nanosilver and nanocurcumin are popular nonmaterial with increasing public attention, but their synergistic therapeutic potentials in burns have never been considered. The present study aimed to provide a novel formulation from both nanomaterials (Ag – Curcumin NPs) and conduct their preclinical evaluation for burn healing. After evaluation of particle size, loading efficiency, release profile ...

Royal Jelly (RJ) is one of the most valued and studied bee products used in medicine cosmetics due to its diverse pharmacological properties. Chemical composition biological activity RJ depends on many factors, including constitution geographical ​​distribution plants, harvest time species. The objective present study was physico-chemical characterization comparison fresh lyophilized RJ; develo...

Multidrug-resistant breast cancers have limited and ineffective clinical treatment options. This study aimed to develop PLGA nanoparticles containing a synergistic combination of vincristine and verapamil to achieve less toxicity and enhanced efficacy on multidrug-resistant breast cancers. The 1:250 molar ratio of VCR/VRP showed strong synergism with the reversal index of approximately 130 in t...

BAckground Thermal stability (TS) is a part of the BCG vaccine characterization by which the consistency of process in BCG vaccine production could be confirmed. To enhance the TS of the vaccine, some prevalent stabilizers in different concentrations were added to the final formulation of BCG bulk prior to Freeze-drying process. We found a formulation more effective than the current stabilizer ...