Although significant progress has been made regarding the structure and function of titin, little data exist on the biosynthesis of this large protein in developing muscle. Using pulse-labeling with [35S]methionine and immunoprecipitation with an antititin mAb, we have examined the biosynthesis of titin in synchronized cultures of skeletal muscle cells derived from day 12 chicken embryos. We fi...

34 Hale, G., Dyer, M. J., Clark, M. R., Phillips, J. M., Marcus, R., Riechmann, L., Winter, G. and Waldmann, H. (1988) Lancet 2, 1394-1395 35 Dyer, M. J. S., Hale, G., Hayhoe, F. G. C. and Waldmann, H. (1989) Blood 73, 1431-1439 36 Waldmann, T. A., Goldman, C. K., Bongiovanni, K. F. et al. (1988) Blood 72, 1805-1816 37 Cheung, N-K., Lazarus, H., Miraldi, F. D. et al. (1987) J. Clin. Oncol. 5, 1...

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Dopamine-containing neurons have been shown to make direct contact with enkephalin-like immunoreactive neurons in the striatum of rat brain (Kubota et al., 1986). Chronic blockade of dopaminergic neurotransmission with the neuroleptic drug haloperidol has been reported to increase the striatal concentration of methionineenkephalin and proenkephalin m R N A (ENK mRNA) (Tang et al., 1983). We inv...

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Emery-Dreifuss muscular dystrophy (EDMD; OMIM # 310300) is an X-linked disease characterized by early contractures of the elbows, Achilles’ tendons and posterior neck, slow progressive muscle wasting and cardiomyopathy with atrioventricular conduction block (Emery and Dreifuss, 1966; Rowland et al., 1979; Emery, 1989). Positional cloning has identified a gene on chromosome Xq28 that is mutated ...

ion or by sequential loss of a *-bond electron and a proton termed an aborted epoxidation by Ortiz de Montellano (1986) and indeed epoxidated products are generated by methane monooxygenase from these substrates (Table 111). Oxidation of Cyclopropylbenzem-Attaching a cyclopropyl ring to the hydroxylated carbon atom of a hydrocarbon substrate as a means of testing for the presence of carbon radi...

euglycemia and survive longer than 200 islets in allogeneic and xenogeneic diabetic hosts. Transplant Proc 1993; 25:953-954. 67. Gotoh M, Maki T, Satomi S, et al: Immunological characteristics of purified islet grafts. Transplantation 1986; 42j387. 68. Klima G, Konigsrainer A, Schmid T, et al: Is the pancreas reo jected independently of the kidney after combined pancreaticrenal transplantation?...

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