National Ambulatory Medical Care Survey data were used to assess outpatient macrolide prescribing and selection. Conditions for which macrolides are firstline therapy represented 5% of macrolide prescribing. Family practitioners selected macrolides for children more frequently than pediatricians. Macrolides are an important antibiotic stewardship target.

The aim of this study was to estimate the effects Japan’s National Action Plan on Antimicrobial Resistance 2016–2020 (NAP) antimicrobial use (AMU). Monthly AMU from January 2013 December 2019 calculated using sales data, and time-series charts were then created for total antimicrobials target drug categories shown in NAP (oral cephalosporins, oral fluoroquinolones, macrolides, parenteral antimi...

Background: Several in-vitro, animal and clinical studies have reported anti-inflammatory activity of macrolides. Antiinflammatory properties of macrolides form the basis for their experimental use in airway inflammatory and infective conditions like asthma Materials and Method: After animal ethics committee approval, the anti-inflammatory and analgesic potentials of erythromycin (40 mg/kg) and...

conclusions although previous studies have shown that a-g transition mutations in 23 srrna gene (domain v) are the main reason for the occurrence of high level macrolides resistance in b. pertussis, however, the mentioned single nucleotide polymorphisms (snps) have not been detected in our resistant strain. this is the first report of high level macrolide resistant b. pertussis, without snps in...

OBJECTIVE To review the mechanisms of action of macrolides in pediatric respiratory diseases and their clinical indications. SOURCES Review in the PubMed database, comprising the following terms in English: "macrolide and asthma"; "macrolide and cystic fibrosis"; "macrolide bronchiolitis and viral acute"; "macrolide and bronchiolitis obliterans" and "macrolide and non-CF bronchiectasis". SU...

Macrolides are known to possess immunomodulatory properties, next to their antimicrobial effects. These immunomodulatory activities have been proven beneficial in chronic pulmonary inflammatory diseases. Whether macrolides also exert favourable immunomodulatory effects during acute inflammation, and therefore can act as adjuvant therapy in community-acquired pneumonia (CAP), is less clear. We a...

Following the first outbreaks of legionnaire’s disease, erythromycin emerged as the treatment of choice without the foundation of rigorous clinical trials. The number of therapeutic failures with erythromycin, as well as the side-effects and drug interactions, led to the consideration of other drugs such as the new macrolides and quinolones for the treatment of legionnaire’s disease in the 1990...