The aim of this study was to determine the impact of diabetic macrosomia on cholesterol and lipoprotein metabolism. Age-related changes in the activities of serum LCAT, hepatic HMG-CoA reductase, cholesterol 7alpha-hydroxylase, and ACAT, the major enzymes involved in cholesterol metabolism, were determined in macrosomic offspring of streptozotocin-induced diabetic rats. Hepatic, serum, and lipo...

Breastfeeding is associated with a lower incidence of obesity, diabetes, and cardiovascular disease later in life. While macrosomic infants have a higher risk of developing obesity and other metabolic disorders. Breast milk may contain special nutrients to meet the different growth needs of different infants. Whether mothers make breast milk different to meet the requirement of macrosomic infan...

BACKGROUND To compare maternal and neonatal outcomes of term macrosomic and adequate for gestational age (AGA) pregnancies. MATERIAL/METHODS A retrospective analysis was performed on all term singleton macrosomic (birth weight ≥4000 g) and AGA (birth weight >10th percentile and <4000 g) pregnancies delivered at our hospital between 2004 and 2008. Data collected included maternal age, gestatio...

A term, male infant weighing 4.725 kg, was born vaginally to a grand multipara, diabetic mother. The birth was difficult and needed assistance with ventose. At 48 hours of birth, the infant noted to be febrile (temperature of 38.5C) with dry skin. Shortly after that, he developed vomiting, loose motions, irritability, and seizure. Examination revealed a macrosomic, normotensive infant, with sli...

Infant birth weight has increased in Ireland in recent years along with levels of childhood overweight and obesity. The present article reviews the current literature on maternal glycaemia and the role of the dietary glycaemic index (GI) and its impact on pregnancy outcomes. It is known that maternal weight and weight gain significantly influence infant birth weight. Fetal macrosomia (birth wei...

bolic disturbances during the pregnancy, and may therefore be termed "macrosomic." Acker et al' reported that the incidence of shoulder dystocia in the deliveries of diabetic mothers was 50%, 23%, and 9% for infants weighing :4500 g, 4000-4499 g, and 3500-3999 g, respectively, compared with 23%, 10%, and 2% for deliveries of non-diabetic mothers. Thus many more infants of diabetic mothers are t...

Controlling the related factors implicated in development of GDM may help to mitigate sharp rise prevalence and its detrimental effects on maternal newborn problems. Maternal age (over 30 years), prior history gestational diabetes, increased BMI, family parity, belonging an ethnic group with a high correlation birth large baby are key GDM. Aim: The main goal is determine frequency diabetes mell...

INTRODUCTION Adipose tissue can release hormones into the blood stream in response to specific extracellular stimuli or changes in metabolic status. Resistin, an adipose-secreted factor, is primarily involved in the modulation of insulin sensitivity and adipocyte differentiation. Adiponectin, an adipocyte-specific hormone with insulin sensitizing, anti-inflammatory and anti-atherogenic effects,...

The aim of this investigation was to determine the time course of changes in serum glucose, insulin and lipid levels, as well as lipid and protein content and lipolytic activities in insulin target organs (liver, adipose tissue and muscle), in macrosomic offspring of streptozotocin-induced mildly hyperglycaemic rats. Food intake and nutritional efficiency were also evaluated. Mild hyperglycaemi...

BACKGROUND Macrosomia is defined as birth-weight over 4,000 g irrespective of gestational age and affects 3-15% of all pregnancies. Aim The present study aimed to determine the relationship between mother's characteristics and macrosomic births and also compare macrosomic and normal newborns regarding the maternal and offspring complications of diabetes during pregnancy. SUBJECTS AND METHODS ...