We study a theoretical model for the toxin-antitoxin (hok/sok) mechanism for plasmid maintenance in bacteria. Toxin-antitoxin systems enforce the maintenance of a plasmid through post-segregational killing of cells that have lost the plasmid. Key to their function is the tight regulation of expression of a protein toxin by an sRNA antitoxin. Here, we focus on the nonlinear nature of the regulat...

Efficient and on-time maintenance plays a crucial role inreducing cost and increasing the market share of an industrial unit. Preventivemaintenance is a broad term that encompasses a set of activitiesaimed at improving the overall reliability and availability of a systembefore machinery breakdown. The previous studies have addressed thescheduling of preventive maintenance. These studies have co...

Reliability-based models are developed and implemented to rationalize current winter layup replacement practices for one-engine and two-engine Great Lakes marine diesel ships. A semi-Markov competing-process approach is used in our models, where the age-dependent system failure behavior is treated as a race among engine components. Howard's one-set competing process model is implemented and ext...

Web applications are growing in demand, complexity and size, thus making it difficult to systematically design and maintain general web applications. To aid in fulfilling these difficult tasks, we present an effective IDE tool to allow the design of web applications at a conceptual level based on a web modeling approach – the WebML with its modeling specifications written in the platform-indepe...

This text describes a simple and effective object oriented software design process template having UML as the modeling language and extensively using inspections to support the construction and maintenance of software products. This software design process uses a sequential organization, based on the waterfall approach, for two reasons: to simplify the explanation of design activities in the co...

Now days, most object-oriented software systems are developed using an evolutionary process model. In evolutionary development lifecycle, it needs to change from time to time. An important kind of change to objectoriented software is Refactoring. The motive of refactoring is to improve the quality of the software system, such as its understandability, extensibility and maintainability, without ...

CM: Problem Management is a detailed problem management process model to be utilised within corrective maintenance. It has been developed at ABB and evaluated for its industrial relevance within 17 non-ABB organisations. In this paper, we present the evaluation results of CM: Problem Management. Our primary goal is to confirm its industrial relevance. Our secondary goal is to establish current ...

This article shows part of the process of designing and modeling a new maintenance management model completely aligned to the quality management standard ISO 9001:2008 and expressed using the Unified Modeling Language (UML); the features of this modeling language gives the possibility of easily integrate the maintenance process into the general information system of an organization and to creat...