Wistar-Furth rats have been shown to be resistant to mineralocorticoid-salt hypertension, but the mechanism for this resistance is unknown. In the current experiments, adult male Wistar and Wistar-Furth rats were given a subcutaneous aldosterone infusion (0.15 microgram/hr) for 4 weeks, and changes in blood pressure and vascular reactivity were studied. Rats received a 1% NaCl, 0.2% KCl solutio...

The industrial solvent trichloroethylene (TCE) has been reported to increase the excretion of formic acid in the urine of male Fischer 344 (F-344) rats following large oral doses. We have examined the dose-response relationship for formic aciduria in male and female Fischer 344 rats, the effect of some known metabolites of TCE and examined the response in male Wistar rats to help understand its...

This paper is focused on affective and cognitive disorders induced by direct exposure to lead chloride (Pb) the possible implication of oxidative stress in male WISTAR rats. Using stereotaxic surgery, a group wistar rats received an intracerebral injection 3 μL (1 mg / L) into right hippocampus or 0.9% Nacl for shame operated controls groups. After 4 days rest, series benchmark neurobehavioral ...

background: tramadol narcotic drugs or epoxied artificial categories is weaker than morphine and stronger than ibuprofen and acetaminophen drug. the aim of this study was to investigate the effect of oral tramadol on some liver enzymes in the rat. materials and methods: in this study, 60 male wistar rats were randomized into three groups (one control group, and experimental groups of 1, and 2)....

Munich Wistar Frömter (MWF) rats develop spontaneous albuminuria that is linked to autosomal genetic loci and inherit a nephron deficit in both female and male animals, respectively. However, albuminuria and kidney damage are clearly more pronounced in males. Here we tested whether androgens and the androgen receptor influence albuminuria in male MWF. We first demonstrated in a pilot study that...

Spontaneously hypertensive heart failure (SHHF) rats develop hypertension and heart failure. We hypothesized that induction of hyperthyroidism should accelerate development of heart failure in male SHHF rats. Male and female SHHF rats received diets containing desiccated thyroid glands (DTG) or a control diet for 8 wk. Male and female Wistar-Kyoto rats were used as normotensive controls. DTG tr...

Previous work from our laboratory indicated that female Wistar rats will self-administer ethanol (EtOH) directly into the posterior ventral tegmental area (VTA). These results suggested that VTA dopamine (DA) neurons might be involved in mediating the reinforcing actions of EtOH within this region. The objectives of this study were to determine (1) the dose-response effects for the self-adminis...

AIM The present study was undertaken to study the pathology and control of sudden unexplained mortality in wistar rats. MATERIALS AND METHODS This study was conducted in a colony of 25 male wistar rats where there was mortality of nine rats. The dead rats were subjected to thorough post-mortem examination and necropsy samples were processed for hematoxylin and eosin staining for histopatholog...

Objective: To determine the regenerating effect of hyaluronic acid on circumferential bone defects in albino Wistar rats. Material and Methods: An experimental type study was designed carried out with 15 male rats, 4 months old weighing between 250 350 grams. Two 3mm diameter 0.8mm deep were created calvaria parietal (on both sides midline). One defect filled a demineralized matrix (control gro...