Paraneoplastic cerebellar degeneration is a rare non-metastatic complication of malignancies. It presents with acute or subacute onset of ataxia, dysarthria and intention tremor. Paraneoplastic cerebellar degeneration is most commonly associated with malignancies of the ovary, breast and lung. The anti-Yo (anti-Purkinje cells) antibodies that specifically damage the Purkinje cells of the cerebe...

Pilonidal disease consists of a hair-containing sinus or abscess occurring most frequently in intergluteal cleft. This disease is generally benign. Although very uncommon entity, it seems reasonable to be aware of possible malignancy in longstanding cases. We report a case of squamous cell carcinoma in a 52- year-old man, with a prolonged history of pilonidal disease and ulceration since 3 mont...

pilonidal disease consists of a hair-containing sinus or abscess occurring most frequently in intergluteal cleft. this disease is generally benign. although very uncommon entity, it seems reasonable to be aware of possible malignancy in longstanding cases. we report a case of squamous cell carcinoma in a 52- year-old man, with a prolonged history of pilonidal disease and ulceration since 3 mont...

We describe an 88-year-old woman with various lesions in the right submammary region that had remained stable for more than 40 years. She reported rapid growth and ulceration of one of the lesions in the past year. The examination showed a firm tumor of diameter 7 cm below the right breast. The surface of the tumor was keratotic at the periphery and ulcerated in the middle with foul-smelling se...

A 55-year-old woman with a history of bipolar affective disorder developed hyperpyrexia, rigidity and depressed consciousness (neuroleptic malignant syndrome) after commencing neuroleptic therapy. On regaining consciousness, she was mute and had signs suggesting pancerebellar involvement. Hyperpyrexia, which is a cardinal feature of neuroleptic malignant syndrome, may have caused cerebellar dam...