Owing to the striking lymphotropsism exhibited by the human immunodeficiency virus, HIV/AIDS patients demonstrate a wide breadth of both benign and malignant lymphoproliferative disorders. These disorders span the spectrum from viral lymphadenopathy to lymphocentric opportunistic infections to proliferations of uncertain and frankly malignant potential. This chapter explores a number of the man...

from both these phenotypically benign lesions had a detectable monoclonal peak, indicating the presence of a clonal T-cell population. Moreover, these monoclonal peaks were identical in base pair size to the diagnostic monoclonal peak detected in the sample that established T-cell malignancy 8 years later. This study validates the usefulness of TCR gene rearrangements in the differentiation of ...

The practical importance of finding a morphologically benign lymphoid aggregate in the bone marrow of patients without known lymphoproliferative disease was assessed in 786 consecutive patients who had had 951 iliac crest bone marrow biopsies performed. Of these, 430 patients known to have lymphoproliferative disease at the time of biopsy were excluded. Of 356 patients, 86 (aggregate group) had...

The T-cell lymphoproliferative disorders are a heterogeneous group of non-Hodgkin's lymphomas (NHL) for which current therapeutic strategies are inadequate, as most patients afflicted with these NHL will succumb to disease progression within 2 years of diagnosis. Appreciation of the genetic and immunologic landscape of these aggressive NHL, including PD-L1 (B7-H1, CD274) expression by malignant...

nant neoplasms of lymphocytes, originating most often from the bone marrow. Lymphoid leukemias can be divided into acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL), depending on the stage of maturation of the neoplastic cells. Lymphoid leukemias are a form of neoplastic lymphoproliferative disease (neoplasia resulting from overproduction of T or B lymphocytes or natural...

The incidence of malignant lymphomas has been increasing in recent years worldwide. These diseases are often accompanied by venous thromboembolic complications (VTEC). development VTEC leads to interrupting therapy, mortality and significant rising treatment costs. Anticoagulants effective prophylaxis. Prescribing anticoagulant therapy is based on different risk scales, which far from perfect. ...

Lymphoproliferative infiltrates could be seen in several skin diseases but they are very characteristic of cutaneous pseudolymphoma, which can mimic both clinically and histopathologically cutaneous malignant pseudolymphoma. A big problem for the clinicians is the differential diagnosis between cutaneous pseudolymphoma and malignant cutaneous lymphomas, as well as possibility for transformation...

UNLABELLED Classical Hodgkin lymphoma (CHL) is a lymphoproliferative disorder that has a bimodal age distribution, affecting young and elderly individuals, and is curable in more than 90% of patients. Here we report the coexistence of cutaneous CHL and malignant melanoma as the presentation of papules and a plaque, in an individual with remote history of systemic CHL. One of the biopsies showed...

We previously reported isolation of human T-cell leukemia virus II (HTLV-II) from a second patient (N.R.A.) with atypical hairy cell leukemia. Follow-up analysis of the characteristics of the patient's HTLV-II infection over a 2-year period has revealed that the patient had two coexistant lymphoproliferative disorders. Oligoclonally integrated HTLV-II was detected in DNA extracted from the pati...

Fine-needle aspiration biopsy (FNA) is an accurate and cost-effective procedure for evaluating salivary gland lesions. Lymphoproliferative lesions may manifest as salivary gland enlargement. We report our experience with 43 cases of reactive and neoplastic lymphoproliferative lesions of the salivary glands evaluated by FNA, including 23 cases of reactive lymphoid hyperplasia and 20 neoplastic l...