qfd is a mechanism for translating the voice of customer into product through various stages of product planning, engineering and manufacturing that widely implemented in modern enterprises throughout the world. in parallel with welcoming to qfd, a lot of academic efforts have gone into improving and completing this method. now traditional methods for determining relative importance of factors ...

Optimizing the manufacturing cost is critical in tolerance synthesis. Decreasing the tolerance range will improve performance but will also increase the manufacturing costs. It is desirable to optimize the tolerance range under such constraints of product design as the relationship between the dimensions of entities of a component and the functional requirement of the design. We propose a const...

QbD is a systemic approach to pharmaceutical development. It means designing and developing formulations and manufacturing processes to ensure predefined product quality. Some of the QbD elements include defining a target product quality profile, designing product and manufacturing processes, identifying critical quality attributes, process parameters, and sources of variability and controlling...

Antibody based products are not widely available to address multiple global health challenges due to high costs, limited manufacturing capacity, and long manufacturing lead times. Nicotiana-based manufacturing of antibody products may now begin to address these challenges as a result of revolutionary advances in transient expression and altered glycosylation pathways. This review provides examp...

The primary purpose of this article is to present a maturity model dealing with environmental manufacturing processes in company. According some authors, Industry 4.0 based on characteristics that have already been the focus “lean and green” concepts. goal was move from resource consumption, pollutant emissions, more extensive towards environmentally responsible (ERM). Using materials methods r...

This study presents a practical framework for introducing lean principles in small manufacturing shops. These shops are characterized by low volume, large variety and one-of-a kind products, accounting for a significant portion of the U.S. manufacturing industry. The potential challenges for adopting a lean system in small manufacturing shops are reviewed. An implementation strategy encompassin...

Multi-attribute auctions allow agents to sell and purchase goods and services taking into account more attributes besides the price (e.g. service time, tolerances, qualities, etc.). In this paper we analyze attributes involved during the auction process and propose to classify them between verifiable attributes, unverifiable attributes and auctioneer provided attributes. According to this class...

Turmoil in the business environment is driving manufacturing companies to become agile. Agility means the capability of operating profitably in a competitive environment of continuous and unpredictable changes with information systems regarded as one of its main enablers. The research presented in this work focuses on the assessment of information systems to support agile manufacturing. The ass...

  This paper demonstrates a preliminary investigation of geometry, function and its relation to DFX principles, namely DFM (Design for Manufacturing). This is the starting point for research on the development of an expert system that assesses design goals along DFX principles in a feature-based CAD environment. There is a need for a deeper level of understanding of the relationship between geo...

Biologic drugs are highly complex molecules produced by living cells through a multistep manufacturing process. The key characteristics of these molecules, known as critical quality attributes (CQAs), can vary based on post-translational modifications that occur in the cellular environment or during the manufacturing process. The extent of the variation in each of the CQAs must be characterized...