Primary cilia are specialised sensory and developmental signalling devices extending from the surface of most eukaryotic cells. Defects in these organelles cause inherited human disorders (ciliopathies) such as retinitis pigmentosa and Bardet-Biedl syndrome (BBS), frequently affecting many physiological and developmental processes across multiple organs. Cilium formation, maintenance and functi...

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 1 wileyonlinelibrary.com through the excitation of OH vibrations.[5] On the other hand, the mechanical properties of supramolecular gels typically suffer from the relatively weak noncovalent interactions among the constituent components.[6] This drawback also limits construction of free-standing objects from the luminescent gels.[7] Herein for ...

ASAP is a comprehensive web-based system for community genome annotation and analysis. ASAP is being used for a large-scale effort to augment and curate annotations for genomes of enterobacterial pathogens and for additional genome sequences. New tools, such as the genome alignment program Mauve, have been incorporated into ASAP in order to improve display and analysis of related genomes. Recen...

The environment in which airlines operate is uncertain for many reasons, for example due to the effects of weather, traffic or crew unavailability (due to delay or sickness). This work focuses on airline reserve crew scheduling under crew absence uncertainty and delay for an airline operating a single hub and spoke network. Reserve crew can be used to cover absent crew or delayed connecting cre...

In adversarial multiagent domains, security, commonly defined as the ability to deal with intentional threats from other agents, is a critical issue. This paper focuses on domains where these threats come from unknown adversaries. These domains can be modeled as Bayesian games; much work has been done on finding equilibria for such games. However, it is often the case in multiagent security dom...

BACKGROUND The development and homeostasis of multicellular organisms depends on sheets of epithelial cells. Bazooka (Baz; PAR-3) localizes to the apical circumference of epithelial cells and is a key hub in the protein interaction network regulating epithelial structure. We sought to identify additional proteins that function with Baz to regulate epithelial structure in the Drosophila embryo. ...

This chapter presents a unified model of Critical Success Factors (CSFs) for ERP implementation projects and the analysis of the relevance of these CSFs along the typical phases of a SAP implementation project. The Accelerated SAP implementation methodology (ASAP) is used as the SAP implementation reference method. Using Process Quality Management method, we derived a matrix of CSFs versus ASAP...

In the fourth quarter of 2000, the first Ariane-5 to carry “piggy-back” payloads on the newly-designed ASAP ring is planned to be launched into a geo-synchronous orbit. The two 100kg spacecraft carried on the ring will be the second generation of microsatellites from the UK Defence Evaluation & Research Agency (DERA), called STRV-1c and –1d. Between them, these spacecraft carry 25 separate expe...

ASAP (a systematic annotation package for community analysis of genomes) is a relational database and web interface developed to store, update and distribute genome sequence data and functional characterization (https://asap.ahabs.wisc.edu/annotation/php/ASAP1.htm). ASAP facilitates ongoing community annotation of genomes and tracking of information as genome projects move from preliminary data...

The extreme genetic heterogeneity of nonsyndromic hearing loss (NSHL) makes genetic diagnosis expensive and time consuming using available methods. To assess the feasibility of target-enrichment and massively parallel sequencing technologies to interrogate all exons of all genes implicated in NSHL, we tested nine patients diagnosed with hearing loss. Solid-phase (NimbleGen) or solution-based (S...