نتایج جستجو برای: massspectrometry
تعداد نتایج: 23 فیلتر نتایج به سال:
Here we present the study of the chromophore structure of the purple chromoprotein from Condylactis gigantea. Tandem mass spectrometry and H and C NMR of the chromopeptide reveal that the protein contains a chromophore with a chemical structure identical to that of the red fluorescent protein from Discosoma sp. A single A63G substitution demonstrates that the nature of the first amino acid of t...
A potent, small molecule inhibitor with a favorable pharmacokinetic profile to allow for sustained SCD inhibition in vivo was identified. Starting from a low MW acyl guanidine (5a), identified with a RapidFire HighThroughput Mass Spectrometry (RF-MS) assay, iterative library design was used to rapidly probe the amide and tail regions of the molecule. Singleton synthesis was used to probe core c...
Immediately after the first MALDI-TOF instrument became available, microbiologists have been investigating its potential as a platform for high throughput identification of microorganisms. A remarkable finding very early in these investigations was that despite the dynamic nature of the bacterial cell, components of the mass spectral profile were sufficiently stable and remained unchanged in sp...
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