نتایج جستجو برای: matrix mini tablets filled capsule system
تعداد نتایج: 2615170 فیلتر نتایج به سال:
A good correlation should be obtained between data derived from in vitro dissolution and bioavailability studies on drug delivery systems if bioavailability parameters are to be reliably predicted from the in vitro dissolution variables. This study compares the in vivo absorption with the in vitro dissolution profiles into various dissolution media of a novel controlled release theophylline cap...
A standard acid resistant microsphere pancreatic enzyme preparation was compared with identical capsules half filled with mini-tablets of a new high lipase preparation in a randomised double blind crossover study in children with cystic fibrosis. Each patient received his/her usual number of capsules and the same dose of lipase during each period of the study. Eighteen patients completed the st...
In this paper, we numerically study the dynamics of (1) a Newtonian liquid-filled capsule in a viscoelastic matrix and that of (2) a viscoelastic capsule in a Newtonian matrix in a linear shear flow using a front-tracking method. The numerical results for case (1) indicate that the polymeric fluid reduces the capsule deformation and aligns the deformed capsule with the flow direction. It also n...
Purpose: To study the impact of a combination cognitive rehabilitation training, butylphthalide soft capsules and ginkgo-leaf tablets on patients with mild Alzheimer’s disease (AD).Methods: One hundred twenty-eight (128) AD were randomly assigned to medication treatment group (MT group, n = 64) joint training (JT 64). Both groups treated tablets, while JT additionally received training. Therape...
Mini-tablets are suitable for paediatric as well geriatric use since they may provide flexible and accurate dosing administration. Due to the minute tablet size, there is a need new standardized quality evaluation procedures conventional techniques have be adopted. The main objective of study was evaluate different dissolution orally disintegrating mini-tablets. Dissolution tests using mini-pad...
Pelletization process first came into existence way back during the 1950s, when the first product was introduced to the market. These pelletized dosage forms have gained popularity considerably from then because of their distinct advantages, such as ease of capsule filling because of better flow properties of the perfectly spherical pellets; enhancement of drug dissolution; ease of coating; sus...
Conventional dry-coating method can cause problems like non-core, double-core, off-center, inlay, and cooking, caused by the core tablet supply system. Hence, dry coating is not as widely used as normal tablets. One-step dry-coating (OSDrC) technology is an innovative one to solve these problems. OSDrC technology, which does not require a separate manufacturing process for the core, can even us...
The hard-shell capsule is a commonly used dosage form, and it has been estimated that approximately 60 billion capsule shells are used annually for pharmaceutical products (Podczeck, 2004). The product essentially consists of a hard shell, usually gelatin based, that is almost always filled with a particulate solid. Among the advantages claimed for the hard-shell capsule compared with tablets a...
The study demonstrates two approaches in formulation of solid oral lipid-based diazepam preparations (BCS class II drug). The aim of the study was to formulate tablets and hard capsules, using emulsifier and adsorbent. Lipidbased preparations improve drug solubility and permeability, i. e. bioavailability. Solid silicate carriers are able to adsorb liquid lipid formulations, resulting in freely...
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