We have recently demonstrated that IgD(hi) B cells can occupy an extravascular perisinusoidal niche in the bone marrow in addition to the well-established follicular niche in conventional secondary lymphoid organs. The spleen has long been considered to be the site at which newly formed B lymphocytes mature into IgD(hi) naive recirculating B cells, but the existence of mutant mice that have sel...

Objective: To histologically compare three different alloplasts and assess bone regeneration Study Design: Bone core of grafts was procured from a grafted site after period 6 months implants were placed. The cores studied at higher magnification formation analyzed. Results: All the showed good results clinically, however β -TCP had shown better more as compared to others. Conclusion: Chronologi...

PURPOSE To examine the influence of ovariectomy (OVX) on bone turnover and trabecular bone mass at the 3 clinically important skeletal sites in mature cynomolgus monkeys. MATERIALS AND METHODS Six female cynomolgus monkeys, aged 17-21 years, were randomized into 2 groups by the stratified weight: the OVX and sham-operation groups (n = 3 in each group). The experimental period was 16 months. L...

In aged mice the population of mature peripheral B cells is maintained despite a severalfold decrease in the population of bone marrow B cell progenitors. The analysis of the rate of accumulation of 5'-bromo-2-deoxyuridine (BrdU)-labeled splenic B cells in mice fed BrdU for 8 days to 8 wk demonstrated a severalfold increase in the half-life of mature B cells in aged mice. Consistent with a role...

Background: Osteoporosis one of the postmenopausal symptoms is characterized by bone loss. There is a link between excessive reactive oxygen species (ROS) formation, estrogen deficiency due to cessation of ovarian function and bone loss. Free radicals are responsible for causing osteoblast apoptosis and reducing osteoblastogenesis in bone remodeling. Vitamin E is a potent antioxidant with the a...

were stained by the same antibody; they were mature eosinophils with segmented nuclei. In a bone marrow biopsy specimen from a patient with hypereosinophilic syndrome, there were also many mature EG2-positive eosinophils. These observations suggest that in asthma eosinophils have already been activated in the early immature stage in the bone marrow. This finding might be related to the pathogen...