The present experiments used 2 versions of a modified Hebb-Williams maze to test the role of the dorsal hippocampus (dHip) and parietal cortex (PC) in processing allocentric and egocentric space during acquisition and retention. Bilateral lesions were made to either the dHip or PC before maze testing (acquisition) or after maze testing (retention). The results indicate that lesions of the dHip ...

The tendency to select T-maze arm that has been changed in brightness between two consecutive trials was investigated under different experimental conditions. In trial 1 rat was confined in maze stem for 10 min and allowed to observe black-and-white arms through transparent partitions. In trial 2 the color of one arm was changed, so that both arms were alike (either white or black) and the rat ...

Tauopathies are neurodegenerative disorders characterized by the accumulation of abnormal tau protein leading to cognitive and/or motor dysfunction. To understand the relationship between tau pathology and behavioral impairments, we comprehensively assessed behavioral abnormalities in a mouse tauopathy model expressing the human P301S mutant tau protein in the early stage of disease to detect i...

This study investigated the effects of perinatal genistein (GEN) exposure on the central nervous system of rat offspring. Pregnant dams orally received GEN (1 or 10 mg/kg/day) or vehicle (1 ml/kg/day) from gestation day 10 to postnatal day 14. In order to assess the effects of GEN on rat offspring, we used a battery of behavioral tests, including the open-field, elevated plus-maze, MAZE and ste...

HIGHLIGHTS: Tumor progression and anxiety depression behaviors under evaluation during propranolol use in murine melanoma. Evaluation of through forced swimming behavior tests, elevated plus maze, open field marble-burying test.

The history of the Porteus Maze Test begins in the period between 1913 and 1915 when it was firsc proposed as a measure to extend the score obtainable wich the early Binet test of intelligence (Porteus, 1959). Porteus uses the analogy of a worked-out mine to point out thac, as a measure of intellect, the use of a single score, thin, 15-min. mencal ability scale has had its day. He feels that ma...

The behavioral activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a selective antagonist of metabotropic glutamate receptor subtype 5 (mGluR5), was assesed in control groups of rats and in rats that underwent short-term hypoxia. MPEP applied intravenously (iv) at the dose of 1 mg/kg was tested using the open field test, the passive avoidance test and the elevated "plus" maze test. MPEP sig...

With a relatively complex maze. reliable forgetting is clearly seen when the training-test interval is 25 days. This forgetting is evidenced by the longer time taken to run the maze and in an increase in the number of errors from the last training trial to the first test trial. In this case. forgetting is a lapse. not a loss. since performance attains the last training trial level at a subseque...

sporadic alzheimer’s disease (sad) is affected by genetic risk factors, aging and oxidative stresses. the herbal extract of r. canina, t. vulgare and u. dioica has a beneficial role in aging, as an anti-inflammatory and anti-oxidative agent. we investigate the neuroprotective effects of this herbal extract in the rat model of sad.  the rats were divided into control, sham, model, herbal extract...

Mouse models have been indispensable for elucidating normal and pathological processes that influence learning and memory. A widely used method for assessing these cognitive processes in mice is the Morris water maze, a classic test for examining spatial learning and memory. However, Morris water maze studies with mice have principally been performed using adult animals, which preclude studies ...