The CYP3A family is a major drug metabolism enzyme in humans. Metabolism-based inhibition of CYP3A might cause clinically significant drug-drug interactions (DDIs). To assess the risk of DDIs caused by metabolism-based inhibition (MBI) of CYP3A, we established an automated single time- and concentration-dependent inhibition assay. To create a diagram to assess DDI risk of compounds in the early...

BACKGROUND Burnout syndrome is under-researched within caregivers (CGs) of children with cerebral palsy. The primary aim was to determine the burnout level of formal CGs of children with cerebral palsy (G1) and to compare it with a control group (G2) of professional pediatric nurses, and second, to correlate the level of depression and anxiety with the burnout level. METHOD In a total sample ...

Unambiguous evidence is presented that the chloride ions play a dual role in formation of micrometre thick film polymerized [Cu-Cl-MBI] n . This occurs when copper exposed to 3 wt.% NaCl solution containing 1 mM mixture inhibitors 2-mercaptobenzimidazole, MBI, and octylphosphonic acid, OPA, molar ratio MBI:OPA 9:1. The act simultaneously as promoter [Cu–MBI] /[Cu–Cl–MBI] reactant incorporated f...

The Infectious Diseases Working Party of the European Blood and Marrow Transplant Group conducted a survey to obtain information about the frequency, presentation, and treatment of mycobacterial infection (MBI) in stem cell transplant (SCT) recipients. Among 29 centers, MBI was diagnosed in 0.79% of 1513 allogeneic and 0.23% of 3012 autologous SCT recipients during 1994-1998 a median of 160 day...

Treatment of sarcoplasmic reticulum membranes with 12 mM-methylbenzimidate (MBI) for 5 min, in the presence of 5 mM-ATP at pH 8.5, resulted in a 2-3-fold stimulation of ATP hydrolysis and over 90%O inhibition of Ca2+ accumulation. This phenomenon was strictly dependent upon the presence of nucleotides with the following order of effectiveness: adenosine 5'-[/,y-imido]triphosphate > ATP > UTP> A...

BACKGROUND The Maslach Burnout Inventory (MBI) is the mainstream measure for burnout. However, its psychometric properties have been questioned, and alternative measurement models of the inventory have been suggested. AIMS Different models for the number of items and factors of the MBI-HSS, the version of the Inventory for the Human Service sector, were tested in order to identify the most ap...

BACKGROUND AND PURPOSE There are little data on the etiology of multiple brain infarcts (MBI) and their impact on clinical outcome in young patients. METHODS We studied 548 MRI-imaged patients (15-49 years) with a first-ever ischaemic stroke. Ischaemic lesions were categorized into three groups: single lesions, MBI in one or >1 circulation territories. Outcomes were unfavorable 3-month modifi...

Mr. Editor: It has been only recently possible to validate the Maslach Burnout Inventory-Human Services Survey (MBI-HSS) 1 among health professionals of Cali 2 , an important step for using this instrument with local empirical support in regard to its reliability of scoring and internal structure. However, two aspects of this analysis can be considered as methodological weaknesses. First, the C...

Most organizations today operate in a highly complex and competitive business environment and need to be able to react to rapidly changing market conditions. IT management frameworks are widely used to provide effective support for business objectives through aligning IT with business and optimizing the use of IT resources. In this paper we analyze three IT management frameworks (ITIL, COBIT an...

The objective of this study is to assess the association between levels of empathy and burnout of emergency professionals in all the assistance levels.A cross-sectional observational study was conducted in the health region of Lleida and the Pyrenees with 100 professionals from the field of Urgency. Participation reached 40.8%. Empathy and burnout were measured using the Spanish versions of the...