نتایج جستجو برای: mcd

تعداد نتایج: 1556  

Journal: :Molecular Vision 2009
Afia Sultana Gordon K. Klintworth Eugene J-M.A. Thonar Geeta K. Vemuganti Chitra Kannabiran

PURPOSE To determine the immunophenotypes of macular corneal dystrophy (MCD) in Indian patients and to correlate them with mutations in the carbohydrate 6-sulfotransferase (CHST6) gene. METHODS Sixty-four patients from 53 families with MCD that were previously screened for mutations in CHST6 were included in an immunophenotype analysis. Antigenic keratan sulfate (AgKS) in serum as well as cor...

Journal: :Journal of lipid research 2006
Gizem Rizki Lorenzo Arnaboldi Bianca Gabrielli Jim Yan Gene S Lee Ray K Ng Scott M Turner Thomas M Badger Robert E Pitas Jacquelyn J Maher

Lipogenic diets that are completely devoid of methionine and choline (MCD) induce hepatic steatosis. MCD feeding also provokes systemic weight loss, for unclear reasons. In this study, we found that MCD feeding causes profound hepatic suppression of the gene encoding stearoyl-coenzyme A desaturase-1 (SCD-1), an enzyme whose regulation has significant effects on metabolic rate. Within 7 days of ...

Journal: :Journal of lipid research 2008
Mary E Rinella Marc S Elias Robin R Smolak Tao Fu Jayme Borensztajn Richard M Green

The methionine choline-deficient (MCD) diet results in liver injury similar to human nonalcoholic steatohepatitis (NASH). The aims of this study were to define mechanisms of MCD-induced steatosis in insulin-resistant db/db and insulin-sensitive db/m mice. MCD-fed db/db mice developed more hepatic steatosis and retained more insulin resistance than MCD-fed db/m mice. Both subcutaneous and gonada...

Journal: :Chest 2002
Norman Wolkove Hany Kamel Michael Rotaple Marc A Baltzan

STUDY OBJECTIVE To determine whether the use of a mucus clearance device (MCD) [Flutter; Axcan Scandipharm; Birmingham, AL] could improve the bronchodilator response to inhaled ipratropium and salbutamol delivered by a metered-dose inhaler in patients with stable, severe COPD. PATIENTS Twenty-three patients with severe COPD were studied. Mean +/- SD age was 71.7 +/- 6.3 years. Mean FEV(1) was...

2017
Gabriel Cara-Fuentes Alfons Segarra Cecilia Silva-Sanchez Heiman Wang Miguel A. Lanaspa Richard J. Johnson Eduardo H. Garin

BACKGROUND Minimal Change Disease (MCD) is the most common type of nephrotic syndrome in children. Angiopoietin-like-4 (Angplt4) has been proposed as mediator of proteinuria in MCD. The aim of this study was to evaluate the role of Angptl4 as a biomarker in MCD. METHODS Patients with biopsy-proven primary MCD, focal segmental glomerulosclerosis, membranous nephropathy (60, 52 and 52 respectiv...

Journal: :Journal of lipid research 2007
Gene S Lee Jim S Yan Raymond K Ng Sanjay Kakar Jacquelyn J Maher

Methionine-choline-deficient (MCD) diets that cause steatohepatitis in rodents are typically enriched in polyunsaturated fat. To determine whether the fat composition of the MCD formula influences the development of liver disease, we manufactured custom MCD formulas with fats ranging in PUFA content from 2% to 59% and tested them for their ability to induce steatohepatitis. All modified-fat MCD...

Journal: :The Journal of arthroplasty 2017
Mark A Snyder Alexandra N Sympson Christina M Scheuerman Justin L Gregg Lala R Hussain

BACKGROUND Aspirin at 325 mg twice daily is now included as a nationally approved venous thromboembolism (VTE) prophylaxis protocol for low-risk total knee arthroplasty (TKA) patients. The purpose of this study is to examine whether there is a difference in deep vein thrombosis (DVT) occurrence after a limited tourniquet TKA using aspirin-based prophylaxis with or without extended use of mechan...

2011
Ji Young Lee Jae Hoon Moon Jong Suk Park Byung-Wan Lee Eun Seok Kang Chul Woo Ahn Hyun Chul Lee Bong Soo Cha

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a major cause of liver-related morbidity and mortality. The underlying mechanisms of disease progression remain poorly understood, and primary therapy of NAFLD is not yet established. We investigated the effects of dietary oleate on the development and progression of NAFLD in a methionine- and choline-deficient (...

2016
Sung-Bae Kim Ok-Hwa Kang Young-Seob Lee Sin-Hee Han Young-Sup Ahn Seon-Woo Cha Yun-Soo Seo Ryong Kong Dong-Yeul Kwon Giovanni Li Volti

Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, has become one of the most common causes of chronic liver disease over the last decade in developed countries. NAFLD includes a spectrum of pathological hepatic changes, such as steatosis, steatohepatitis, advanced fibrosis, and cirrhosis. Bisdemethoxycurcumin (BDMC) is polyphenolic compounds with a d...

2003
E. I. SOLOMON M. L. NEIDIG G. SCHENK

Magnetic circular dichroism (MCD) spectroscopy and variable-temperature variable-field (VTVH) MCD are powerful methods for studying the excited and ground states of paramagnetic systems. Notably, these methods provide detailed insight into the geometric and electronic structures of catalytically active centers in inorganic and biological systems. In this review, we present the theoretical backg...

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