Background: Differences in emotion processing during Major Depressive Disorder (MDD) have not been well explored as a potential explanation for age and gender disparities in rates of depression and depressive symptoms. Early studies by our group demonstrated that those with MDD underperform in emotion processing of faces, although recently we showed a selective decrement in young women with MDD...

Background: Major Depression Disorder (MDD) is a common disorder with preva-lence of 15% among men and up to 25% among women. In recent years the association of immune system alterations and MDD has been investigated. Assessments of immu-nologic and inflammatory responses in these patients enhance our knowledge of the eti-ology and pathogenesis of this disease. Objective: To investigate the cha...

Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWAS mega-analysis for MDD. In the MDD discovery phase, we analyzed more than 1.2 million autosomal and X chromosome single-nucleotide polymorphisms (SNPs) in 18 759 independent and unrelated subjects of rec...

Visualizing information enables humans to capture, understand, and analyze them in an efficient way. Tools providing such visualization possibilities are omnipresent in software development processes and still subject to current research. While visualization is widely tried in classical software development, the application to MDD is much less common, but still desperately needed. In this paper...

background: major depression disorder (mdd) is a common disorder with preva-lence of 15% among men and up to 25% among women. in recent years the association of immune system alterations and mdd has been investigated. assessments of immu-nologic and inflammatory responses in these patients enhance our knowledge of the eti-ology and pathogenesis of this disease. objective: to investigate the cha...

BACKGROUND Limited successes of gene finding for major depressive disorder (MDD) may be partly due to phenotypic heterogeneity. We tested whether the genetic load for MDD, bipolar disorder, and schizophrenia (SCZ) is increased in phenotypically more homogenous MDD patients identified by specific clinical characteristics. METHODS Patients (n = 1539) with a DSM-IV MDD diagnosis and control subj...

BACKGROUND Major depressive disorders (MDD) is a common mental disorder with high prevalence, frequent relapse and associated with heavy disease burden. Heritability, environment and their interaction play important roles in the development of MDD. MDD patients usually display a wide variation in clinical symptoms and signs, while the diagnosis of MDD is relatively subjective. The treatment res...

Recent studies have found high rates of familial aggregation of major depression (MDD) in relatives of depressed children coming for treatment, leading investigators to suggest that probands for genetic studies of MDD should be selected from samples of depressed children being brought for treatment. Implicit in this recommendation is the assumption that childhood and adult depression are simila...

Major depressive disorder (MDD) is the most common non-motor manifestation of Parkinson's disease (PD) affecting 50% of patients. However, little is known about the cognitive correlates of MDD in PD. Using a computer-based cognitive task that dissociates learning from positive and negative feedback, we tested four groups of subjects: (1) patients with PD with comorbid MDD, (2) patients with PD ...