The chronobiological effect on the pharmacokinetics of liposomal encapsulated ampicillin (LEA) was compared at noon (1200) and midnight (2400) after intravenous injection of 50 mg/kg of LEA in rats. The effects of fasting on the circadian rhythms of LEA were also investigated. Serial blood samples were collected for 2 h. Bile and urine were collected during the entire study. Plasma data was ana...

We investigate fluid transport in random velocity fields with unsteady drift. First, we propose to quantify fluid transport between flow regimes of different characteristic motion, by escape probability and mean residence time. We then develop numerical algorithms to solve for escape probability and mean residence time, which are described by backward Fokker-Planck type partial differential equ...

Characteristic times for transport processes in biological systems may be evaluated as mean transit times (MTTs) (for transit states) or mean residence times (MRT) (for steady states). It is shown in a general framework of a (linear) reaction–diffusion–convection equation that these two times are related. Analytical formulas are also derived to calculate moments of exit time distribution using ...

Quantitative knowledge of stabilizationand decomposition processes is necessary to understand, assess and predict effects of land use changes on storage and stability of soil organic carbon (soil C) in the tropics. Although it is well documented that different soil types have different soil C stocks, it is presently unknown how different soil types affect the stability of recently formed soil C...

BACKGROUND AND AIMS Leaf longevity is controlled by the light gradient in the canopy and also by the nitrogen (N) sink strength in the plant. Stand density may influence leaf dynamics through its effects on light gradient and on plant growth and reproduction. This study tests the hypothesis that the control by the light gradient is manifested more in the vegetative period, whereas the opposite ...

Continuous processes offer more environmentally friendlier beer production compared to the batch production. However, continuous of mashing has not become state-of-the-art in brewing industry. The controllability and flexibility this process still hurdles for practical implementation, but which are necessary react changing raw materials. Once overcome, a can be efficiently adapted Both mean res...

This paper examines how the combination of simulated discharge and mean catchment residence time (MRT) may be used to subsume flow path process complexity and provide a simple, scalable evaluative data source for water quantity-quality based conceptual models at the catchment scale. A simple Monte Carlo framework is used to evaluate the identifiability of parameters, and how values of mean resi...