two new potential magnetic resonance imaging contrast agents, gd-hematoporphyrin (gd-h) and gd-tetra-carboranylmethoxyphenyl-porphyrin (gd tcp), were synthesized and applied to nude mice with human melanoma (mm 138) xenografts. these agents showed a high relaxivity because of their greater potential to coordinate water molecules. the reduction of t1 relaxation times of 16 and 21% was observed i...

Background: P53 tumor suppressor gene mutation is one of the most common genetic alterations in human malignancies. The mutated from of the gene is stable and can be detected with immunohistochemistry methods. There is much controversy about the expression rate of this gene in malignant melanoma. Objective: To determine the frequency of the P53 antigen expression by sex, age, type and thickness...

Desmoplastic melanoma(DM) is a subtype of malignant melanoma, and there are very few reports on the occurrence this disease in oral region. Since DM mainly composed achromatic spindleshaped tumor cells, its clinical histopathological diagnoses difficult. However, immunohistochemical staining useful for diagnosis DM.

Melanoma skin cancer is one of the most dangerous types cancer, which, if not diagnosed early, may lead to death. Therefore, an accurate diagnosis needed detect melanoma. Traditionally, a dermatologist utilizes microscope inspect and then provide report on biopsy for diagnosis; however, this process easy requires experience. Hence, there need facilitate while still yielding diagnosis. For purpo...

Two new potential magnetic resonance imaging contrast agents, Gd-hematoporphyrin (Gd-H) and Gd-tetra-carboranylmethoxyphenyl-porphyrin (Gd TCP), were synthesized and applied to nude mice with human melanoma (MM 138) xenografts. These agents showed a high relaxivity because of their greater potential to coordinate water molecules. The reduction of T1 relaxation times of 16 and 21% was observed i...

Subungual melanoma is a rare subtype of melanoma. usually presents as discoloration the nail, nail splitting, or bed bleeding and may easily be misdiagnosed onychomycosis bacterial infection. Furthermore, secondary infections are possible, which could lead to late diagnosis. For this reason, most subungual melanomas diagnosed in advanced stages associated with poor prognosis. We present case 90...

purpose: to report a rare malignant melanoma with chalazion-like presentation.  case report: a 36-year old woman with a chalazion-like mass in the left upper lid, having been resected twice, was referred to our center for the management of recurrence. the total resection of the suspicious area was done. histopathologic examination confirmed the diagnosis of malignant melanoma. the appropriate r...

Background. Malignant neoplasms of the skin are fairly common tumors in world population and among Ukraine. The main method diagnosing skintumors is a biopsy, which allows establishing diagnosis at an early stage ensures cure most patients.
 Purpose. To evaluate modern recommendations for biopsy dermato-onсological diseases.
 Materials methods. search sources information was conducted...