نتایج جستجو برای: meleda disease
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Mal de Meleda is a rare transgressive palmoplantar keratoderma with an estimated prevalence of 1 in 100,000 individuals. It was first described in 1826 by Stulli on the island of Mljet. Its autosomal recessive inheritance was described in 1938, and the defective gene was localized to chromosome 8 qter in 1998. Clinical features are the result of abnormal palmoplantar keratinization and include ...
BACKGROUND Inactivation of wild type P53 by its main cellular inhibitors (MDM2 and MDMX) is a well recognised feature of tumour formation in liposarcomas. MDM2 over-expression has been detected in approximately 80% of liposarcomas but only limited information is available about MDMX over-expression. To date, we are not aware of any study that has described the patterns of MDM2 and MDMX co-expre...
While the first traces of interest in skin diseases date back to the 14(th) century recipes from Glagolitic manuscripts, the scientific beginnings of dermatovenereology might be associated with the beginning of the 19(th) century, when in the Rijeka region a 'new disease', called after the village of Škrljevo, was studied by Giovanni Battista Cambieri. This, however, has not been the only disea...
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