Pelletization is an agglomeration process that converts fine powders or granules of bulk drugs and excipients into small, free flowing, spherical or semi-spherical units, referred to as pellets. This review outlines manufacturing of spherical pellets. The manufacturing techniques include Drug layering, Extrusion-Spheronization, Cryopelletization, Compression, Balling, Hot-Melt Extrusion Technol...

As is well known, the extrusion rate of polymers from a cylindrical tube or slit (a "die") is in practice limited by the appearance of "melt fracture" instabilities which give rise to unwanted distortions or even fracture of the extrudate. We present the results of a weakly nonlinear analysis which gives evidence for an intrinsic generic route to melt fracture via a weakly nonlinear subcritical...

Polymers are known to exhibit various flow instabilities during extrusion in which a molten polymer is forced to flow through a narrow die, in order to form a strand or acquire a desired shape of the final product. Recent developments in experimental techniques revealed that some of the instabilities are interfacial in nature, that is originate from the violation of the no-slip boundary conditi...

Article history: Received on: 12/06/2013 Revised on: 16/09/2013 Accepted on: 17/10/2013 Available online: 31/10/2013 Tuberculosis has metamorphosized over the decades from drug resistant to multidrug resistant to the lethal extensively drug resistant forms lately. With scarce newer anti-TB drugs emerging, there is a pressing need to ameliorate the current treatment therapy by modulating the for...

The thermal stability of polyethylene oxide (PEO) in sustained release tablets prepared by hot-melt extrusion was investigated. The weight average molecular weight of the polymer was studied using gel permeation chromatography. The chemical stability of PEO was found to be dependent on both the storage and processing temperature, and the molecular weight of the polymer. Storage of the polymer a...

The UK Dairy Roadmap has set a target of achieving 50 wt.-% high density polyethylene (HDPE) recyclate in their HDPE milk bottles. Such content will lead to the accumulation recyclates that have been subjected different number melt extrusion cycles supply chain. This work investigates structure-property relationship blending virgin (vHDPE) with these grades repeatedly melt-extruded (rHDPE). was...

LDPE remains the classic material of choice for many Extrusion Coating Applications, due to excellent processing and end-use performance reasons. High shear extrusion screws are desirable, actually promoting oxidation of the melt for improved adhesion to substrates. T-shaped flat die technology, with internal deckling, has emerged as the premium technology to handle monolayer and multilayer ext...