Objective(s): The present study aims to evaluate the protective effect of the compounds isolated from Echinophora cinerea (E. cinerea) against oxidative stress and apoptosis induced by cisplatin (CIS) in PC12 cells. Materials and Methods: Six compounds were isolated as quercetrin-3-O-β-D-glucopyranoside (QUE), osthol (OST), verbenone-5-O-β-D-glycopyranoside (VER), Isoimperatorin (ISO), kaempfer...

in this study, a mixed matrix polyethersulfone/iron-nickel oxide nanoparticle nanofiltration membrane was prepared by the solution casting technique. polyvinylpyrrolidone was also used as a membrane pore former in membrane fabrication. the effect of iron-nickel oxide nanoparticles concentration in the casting solution on the membrane structure and performance was investigated. scanning optical ...

introduction: gp63 is a major surface protease of leishmania promastigotes that plays an important role in its virulance. as gp63 on its own can not develop an effective protection against leishmaniasis, the goal of this study was to evaluate the protective effect of gp63 conjugated with tetanus toxoid (tt) and vitamin d3 in susceptible balb/c mice against cutaneous leishmaniasis. methods: this...

Outer membrane protein I (OprI) is one of the major proteins of the outer membrane of Pseudomonas aeruginosa. The protective effect of OprI vaccination and that of three OprI-specific monoclonal antibodies (MAbs) against infection with P. aeruginosa were tested in immunosuppressed mice. The combination of Oprl and MAb 2A1 protected the mice against a challenge with a 96-fold 50% lethal dose. Th...

Oxidative damage by reactive oxygen species (ROS) is a major cause of sperm dysfunction. Excessive ROS generation reduces fertilization and enhances DNA damage of spermatozoa. Interaction between spermatozoa and oviductal epithelial cells improves the fertilizing ability of and reduces chromatin damage in spermatozoa. Our previous data showed that oviductal epithelial cell membrane proteins int...

Gangliosides are normal constituents of the plasma membrane. Exogenous gangliosides can be incorporated into the membrane and extensive research in nervous tissue has demonstrated a beneficial effect of gangliosides on the functional recovery of lesioned neurons and protection against neurotoxins. This paper shows that the effect of gangliosides is not restricted to neurons. The monosialogangli...

conclusions cornus mas fruit extract effect may be due to including some antioxidant components, which caused membrane stabilizing and normalization of fluctuated biochemical profiles induced by ccl4 exposure. our results validated the traditional use of cornus mas in the treatment of liver disorders. results oral administration of cornus mas fruits extract to rats for 14 days provided a signif...