The traditional approach to dosing anticancer drugs is to administer a standard starting dose, which is normalized to body surface area, and then to adjust or individualize subsequent doses based on the severity of ensuing drug toxicity. Dosing according to body surface area is based on the assumption that the volume of distribution and drug elimination mechanisms are proportional to the body s...

A sensitive electrochemical sensor was developed using reduced graphene oxide RGO-Cu2O/Fe2O3 nanocomposite for 6-mercaptopurine detection based on a facile fabrication method. The surface morphology and structural composition of this evaluated by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), Fourier transform infrared (FT-IR) spectroscopy. screen-printed graphit...

Mercaptopurine is a medicine used to prevent the formation and spread of cancer cells. Mercaptopurine, known chemically as 1,7-dihydro-6H-purine-6-thione, is an analogue of the purine bases adenine and hypoxanthine. This work reports an investigation of anticancer drug Mercaptopurine with the combined density functional theory and Its structure were optimized at B3LYP/6-31G*, level and The mole...

Mercaptopurines have been used as anticancer agents for more than 40 years, and most acute lymphoblastic leukemias are treated with 6-mercaptopurine (6MP) or 6-thioguanine (TG). Overexpression of the two related multidrug resistance proteins MRP4 and MRP5 has been shown to confer some resistance against mercaptopurines, which has been attributed to extrusion of mercaptopurine metabolites by the...

Elion, Burgi, and Hitchings (3) synthesized 6-mercaptopurine and found it to be a purine an tagonist in Laclobacillus casei which was reversible by adenine, guanine, xanthine, and hypoxanthine, but not by folie acid (4). They also observed that resistance of L. casei to 6-mercaptopurine was not accompanied by resistance to adenine antagonists such as 2,6-diaminopurine, 8-azaadenine, and purine,...

6-Mercaptopurine, a hypoxanthine antimetabolite, is used in the treatment of acute lymphoblastic leukemia (ALL) in children. Extensively metabolized before it exerts cytotoxic action, it is catabolized into 6-mercapto-2,8-dihydroxypurine (thiouric acid), which is excreted by the kidneys. We describe a metabolite of 6-mercaptopurine, 6-methylmercapto-8-hydroxypurine, whose presence has not been ...

Objectives This is a protocol for Cochrane Review (intervention). The objectives are as follows: To determine the efficacy and safety of 6?thioguanine nucleotide (6?TGN) metabolite?based dosing strategy maintenance remission using azathioprine or mercaptopurine in Crohn's disease ulcerative colitis.

6-Mercaptopurine and related purine antimetabolites are used in the treatment of several B cell disorders. These drugs inhibited the proliferation of mature splenic B cells after being triggered with polyclonal mitogens. In addition to the antiproliferative effects, 6-mercaptopurine, 2-mercaptopurine, and aminoguanidine evoked a rapid apoptotic cell death in activated B cells that started at 6 ...

OBJECTIVES Mycobacterium avium subspecies paratuberculosis (MAP) has been targeted for treatment with clarithromycin and rifamycin derivatives in numerous cases of Crohn's disease (CD). 6-Mercaptopurine and its pro-drug azathioprine are widely used as immunomodulators in the treatment of CD and have recently been shown to have anti-MAP activity in vitro. The objectives of the study were to eval...