Abstract Gliomas have been classified into molecular (proneural, classical, mesenchymal) and neurodevelopmental (astrocyte, mesenchymal, neural progenitor cell (NPC), oligodendrocyte (OPC)) subtypes describing inter- intra-tumoral heterogeneity; however, the functional outcomes therapeutic implications of these has yet to be fully described. Metabolic reprogramming is a hallmark cancer, maligna...

This case report is a 65 year old woman from Kerman. Her main complian is nasal obstruction and recurrent nasal bleeding from five months ago. In clinical examination there was a large tumor in left nasal cavity. CT scaning revealed a large tumor in left nasal cavity and maxillary sinuse. The tumor is resected compeletely with negative safe margine by radical caldwell- luc approach. The origin ...

Calcifying fibrous tumor (CFT) is a rare mesenchymal tumor, affecting children and young adults with a predilection for the soft tissue and the abdominal cavity. CFT of the tubular gastrointestinal tract is very rare with less than 20 cases of gastric CFTs reported in English literature. This benign hypocellular fibrosclerotic calcifying lesion can resemble other spindle cell tumors particularl...

Mesenchymal stem cells are important cells in tumor microenvironment. We have previously demonstrated that IL-17B/IL-17RB signal promoted progression of gastric cancer. In this study, we further explored the effect of IL-17B on mesenchymal stem cells in tumor microenvironment and its impact on the tumor progression. The results showed that IL-17B induced the expression of stemness-related genes...

Inflammatory fibroid polyp is a benign mesenchymal tumor most commonly arising in the stomach and ileum. It needs to be distinguished from other tumors of GIT which done with help morphological features IHC.

The oncofetal IGF2 mRNA-binding protein 1 (IGF2BP1) controls the migration and invasiveness of primary as well as tumor-derived cells in vitro. Whether the protein also modulates epithelial-mesenchymal-transition (EMT), a hallmark of tumor progression involved in tumor cell dissemination, remained elusive. In this study, we reveal that IGF2BP1 enhances mesenchymal-like cell properties in tumor-...

Tumor necrosis factor-alpha is a critical pro-inflammatory cytokine produced by macrophages and was once considered an anti-tumor agent. However, a low dose of tumor necrosis factor-alpha can cause epithelial mesenchymal transition, angiogenesis and metastasis. NF-κΒ contributes to epithelial mesenchymal transition induced by tumor necrosis factor-alpha. Kanglaite, an extract from the Coix lacr...

Abstract Glioblastoma (GBM), a high grade brain tumor, possesses poor overall survival with less than 5% surviving past five years. Previously, the TCGA classifications for GBM have included mesenchymal, proneural, classical and neural subtypes their own respective expression profiles survival. Recent omics analysis has revealed other key aspects of pathology, including intratumoral heterogenei...

A 3D tumor microenvironment model is presented, combining hyaluronic acid (HA) and alginate. The can be used to mimic the bioactivity of HA in gastric cancer, as well crosstalk between cancer cells mesenchymal stem cells.