The prefrontal cortex (PFC) plays a central role in processing both normal and pathological affective states and it is among the brain regions most closely associated with stress-related psychopathology in humans. The ventromedial PFC (vmPFC) in particular has been shown to be required for healthy emotional regulation, social function and risk assessment and decision-making. Also this region ex...

Bruxism is an involuntary grinding of the teeth which can occur during daytime or night. An estimated 85–90% of the population brux at some time during their lives, but it is clinically significant in only 5% of them. In such cases it can result in significant periodontal damage and can produce significant sleep disturbance in the bed partner of the person (Moore et al., 2000). Reports of SSRI-...

KOOLHAAS, J. M., F. MORA AND A. G. PHILLIPS.Effects o f food and water deprivation on self.stimulation o f the medial and sulcal prefrontal cortex and caudate putamen in the rat. PHYSIOL. BEHAV. 18(2) 329-331, 1977. Self-stimulation rates from electrodes, implanted in the terminal areas of the mesocortical and nigrostriatal dopaminergic systems, were measured during food or water deprivation. A...

The P300 is a known ERP component assessing stimulus value, including the value of a monetary reward. In parallel, the incentive value of reinforcers relies on the PFC, a major cortical projection region of the mesocortical reward pathway. Here we show a significant positive correlation between P300 response to money (vs. no money) with PFC gray matter volume in the OFC, ACC, and dorsolateral a...

In neurodegenerative disorders, such as Parkinson's disease (PD), alpha-synuclein (α-syn) accumulates to induce cell death and/or form a cytoplasmic inclusion called Lewy body (LB). This α-syn-related pathology is termed synucleinopathy. It remains unclear how α-syn accumulation expands during the progress of synucleinopathy in the human brain. In our study, we investigated the patterns of dist...

the objective of this study was to observe the apoptosis-inducing effect and mechanism of baicalin on human cervical cancer hela cells. the inhibitory effect of baicalin on the growth of hela cells was measured by mtt assay, and cell proliferation and migration was analyzed by cell scratch assay. morphological changes of apoptotic cells were viewed by the light microscope and electron microscop...