نتایج جستجو برای: metabolome
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Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal fluid, urine and blood. As part of an ongoing effort to...
An ongoing challenge in biology is to predict the phenotypes of individuals from their genotypes. Genetic variants that cause disease often change an individual's total metabolite profile, or metabolome. In light of our extensive knowledge of metabolic pathways, genetic variants that alter the metabolome may help predict novel phenotypes. To link genetic variants to changes in the metabolome, w...
Donor urine obtained for a drug study was collected from donors reporting no use of prescription, overthe-counter or herbal preparations in the eight days prior to donation. However, LC/MS analysis showed that a number of non-endogenous compounds were detected in this urine. To identify the compounds, information from the mass spectral data set was used in a search of the Human Metabolome datab...
An organism’s metabolome is the cataloguing of the entire set of metabolites found in the organism. It is dynamic and thus just a snapshot of the processes going on in the organism at one specific time point. When combined with other ‘‘omics’’ data, a more complete understanding of the organism emerges (Fiehn et al., 2000). However, several technical challenges to obtaining a metabolomic profil...
In our previous works we established that in an autoinflammatory condition, familial Mediterranean fever (FMF), the gut microbial diversity is specifically restructured, which also results in the altered profiles of microbial long chain fatty acids (LCFAs) present in the systemic metabolome. The mainstream management of the disease is based on oral administration of colchicine to suppress clini...
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