The advent of high-performance computing has benefited various disciplines in finding practical solutions to their problems, and our health care is no exception to this. Signal processing, image processing, and data mining tools have been developed for effective analysis of medical information, in order to help clinicians in making better diagnosis for treatment purposes. Data mining has become...

Schizophrenia is a neuropsychiatric disorder affecting 1% of the world’s population. Due to a broad range of symptoms and wide heterogeneity, current therapeutic approaches in schizophrenia fail to treat all symptomatic manifestations of the disease. Therefore, new models that reproduce core pathological features of schizophrenia are needed for the elucidation of unidentified pathological disea...

Borna disease virus (BDV) persists in the central nervous systems of a wide variety of vertebrates and causes behavioral disorders. Previous studies have revealed that metabolic perturbations are associated with BDV infection. However, the pathophysiological effects of different viral strains remain largely unknown. Rat cortical neurons infected with human strain BDV Hu-H1, laboratory BDV Strai...

Pharmaco-metabonomic profiling as a predictor of toxicity in patients with inoperable colorectal cancer treated with capecitabine Authors: Alexandra Backshall, Rohini Sharma, Stephen J. Clarke, Hector C. Keun Biomolecular Medicine, Dept of Surgery & Cancer, Faculty of Medicine, Imperial College London South Kensington Campus, Exhibition Rd, London SW7 2AZ, UK Division of Investigative Sciences,...

In this paper we present case studies in conducting integrated data and text mining activities within the Discovery Net project. We discuss how our open infrastructure provides a powerful workbench for the dynamic analysis and interpretation of bioinformatics data. Our examples include using text mining to aid the interpretation of gene expression data and also in relating metabonomic experimen...

Toxicogenomics is a rapidly developing discipline that promises to aid scientists in understanding the molecular and cellular effects of chemicals in biological systems. This field encompasses global assessment of biological effects using technologies such as DNA microarrays or high throughput NMR and protein expression analysis. This review provides an overview of advancing multiple approaches...

Background: The impact method was used to make unilateral femoral comminuted fractures in tree shrews, which were then intravenously injected with lipopolysaccharide create a traumatic systemic inflammatory response syndrome model. Methods: treatment group infused shrew umbilical cord mesenchymal stem cells via the tail vein. After 10 days of treatment, 6 shrews killed control, model and groups...

The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazi...