On November 23, 2015, the US Food and Drug Administration (FDA) approved nivolumab for treatment of metastatic renal cell carcinoma (RCC), thus opening a new era immunotherapy this tumor. This review summarizes 5-year experience studying using in RCC patients.

BACKGROUND We report an unusual case of a synchronous rectal and metachronous vaginal metastatic renal cell carcinoma. CASE PRESENTATION A 78-year-old woman presented with hematochezia and a colonoscopy revealed a metastatic clear-cell renal cell carcinoma rectal polyp biopsy-proven. Abdominal computed tomography identified a 9.0-cm left renal mass with renal vein thrombosis, for which she un...

CONTEXT Pancreatic involvement from metastatic renal cell carcinoma accounts for 0.25-3% of the cases. The distinction between primary pancreatic clear cell tumour and metastatic deposits from renal cell carcinoma may lead to diagnostic difficulties. Usually metastasis from renal cell carcinoma presents many years after the primary tumour has been resected. A typical metastatic lesion in pancre...

t Renal cell carcinoma is one of the highly aggressive tumors and notorious for late presentations. It is associated with high morbidity and mortality. Renal cell carcinoma is known for rare metastatic sites. In clinical practice, it is often important not to anchor to a particular diagnosis but rather revisit and revaluate entire history and clinical examination. We describe a case of metastat...

OBJECTIVE Metastatic disease occurs in a significant percentage of patients with renal cell carcinoma. Recent advances in systemic therapies for metastatic renal cell carcinoma are likely to have a significant effect on the way patients with advanced disease are imaged. These new therapies have shown a significant increase in progression-free survival. CONCLUSION Imaging is likely to play an ...

Approximately 15% of renal cell carcinomas metastasize to the head and neck region. Here in, we report a rare case patient who underwent nephrectomy for carcinoma (RCC) ten years ago presented with metastatic on her lower lip. A 65-year-old woman rapidly growing mass Pathology resulted in metastasis. Although is uncommon, metastasis should be considered differential diagnosis vascular lesion ar...

Advances in surgical techniques and laparoscopic instruments have resulted in the development of laparoscopic pancreatic surgery. Total pancreaticoduodenectomy is performed for treating benign and borderline pancreatic disease involving the whole pancreas. Here, we report a case of metastatic renal cell carcinoma in the pancreas, treated by laparoscopic pylorus-preserving total pancreaticoduode...

Metastasis seriously affects the clinical outcome of renal cell carcinoma patients. Despite the approval of several targeted therapies that have led to an improvement in the progression-free survival rate for these patients, advanced and metastatic renal cell carcinoma remains difficult to treat. Recently, microRNAs have been found to play a critical role in the metastatic dissemination of rena...

Approximately 15% of renal cell carcinomas metastasize to the head and neck region. Here in, we report a rare case patient who underwent nephrectomy for carcinoma (RCC) ten years ago presented with metastatic on her lower lip. A 65-year-old woman rapidly growing mass Pathology resulted in metastasis. Although is uncommon, metastasis should be considered differential diagnosis vascular lesion ar...

BACKGROUND Renal cell carcinoma metastasizing to rectum is very rare, and the unusual metastatic sites should be paid attention to during the follow-up of renal cell carcinoma. CASE SUMMARY We describe a case of a 65-year-old male who was diagnosed with metastatic renal cell carcinoma to rectum 10 years after the right radical nephrectomy. Histopathology and immunohistochemical examinations c...