Introduction Methamphetamine and amphetamine, powerful CNS stimulants that have a variety of ethical uses, have side effects of increased confidence, sociability, and energy that have resulted in their extensive abuse as recreational psychoactive drugs. This extends to their abuse in sports because of the additional properties of increased mental alertness and suppression of fatigue.1 Negative ...

Methamphetamine is a psychostimulant that was initially synthesized in 1920. Since then it has been used to treat attention deficit hyperactive disorder (ADHD), obesity and narcolepsy. However, methamphetamine has also become a major drug of abuse worldwide. Under conditions of abuse, which involve the administration of high repetitive doses, methamphetamine can produce considerable neurotoxic ...

Methamphetamine is a potent psychomotor stimulant and a major drug of abuse. There is currently no effective medication available for treatment for methamphetamine addiction. The present study investigated the role of the dopamine D3 receptor on IV methamphetamine self-administration and its effect on methamphetamine induced neurochemical changes. Acute administration of the putative D3 recepto...

AACP.com Annals of Clinical Psychiatry | Vol. 25 No. 2 | May 2013 153 Cocaine abuse epidemics come and go. Some of us remember the cocaine epidemic of the 1980s that peaked in 1985 and produced an estimated 2.5 million lifetime stimulant abusers (p 3). Some may assume cocaine abuse was a big problem but hopefully isn’t big anymore. Unfortunately, it still is, and we are facing yet another epide...

INTRODUCTION Methamphetamine is a powerful psychostimulant that causes significant neurological impairments with long-lasting effects and has provoked serious international concerns about public health. Denial of drug abuse and drug craving are two important factors that make the diagnosis and treatment extremely challenging. Here, we present a novel and rapid noninvasive method with potential ...

The abuse of methamphetamine (MA) is to date detected and subsequently verified through the monitoring MA its metabolites within biological specimens.

Methamphetamine is a stimulant commonly abused in many parts of the United States. Most methamphetamine users are white men 18 to 25 years of age, but the highest usage rates have been found in native Hawaiians, persons of more than one race, Native Americans, and men who have sex with men. Methamphetamine use produces a rapid, pleasurable rush followed by euphoria, heightened attention, and in...

background: the use of methamphetamine and other drugs among young adults has been a theme of growing interest and concern on the part of researchers and health associations. this paper reports recent use of methamphetamine and its relation with some demographic variables among substance users in west of iran. method s: this cross-sectional study was carried out on 559 substance users of hamada...

BACKGROUND Methamphetamine is a major drug of abuse with no effective pharmacotherapy available. Trace amine associated receptor 1 is implicated in cocaine addiction and represents a potential therapeutic target. However, the effects of trace amine associated receptor 1 agonists on addiction-related behavioral effects of methamphetamine are unknown. METHODS This study examined the effects of ...

In healthy human volunteers, we have previously shown that isradipine, a dihydropyridine-class calcium-channel antagonist, reduces some methamphetamine-induced positive subjective effects associated with its abuse liability, presumably by antagonizing cortico-mesolimbic dopamine pathways. In the present study, we combined acute immediate-release (IR) isradipine with repeated sustained-release (...