Introduction Polymethylmethacrylate bone cement has been frequently used as an adjunctive material in the limb salvage surgery for malignant bone tumors. The purpose of this study is to investigate the feasibility of bone cement as a vehicle of methotrexate for local treatment of osteosarcoma, and the cytotoxic effect of the eluted methotrexate on the osteosarcoma cells. Also we evaluated the c...

Aims: Response of single agent chemotherapy in improving quality of life in patients with recurrent head and neck cancers. Methods and material: This is a study of the 18 patients with advanced cancers of head and neck, who had failed earlier attempts of radical treatment with Surgery, Radiotherapy ± chemotherapy and have residual or recurrent tumours, were treated with single agent Injection M...

Children with acute lymphocytic leukemia, who were in remission after induction with prednisone and vincristine and consolidation with intravenous methotrexate, were randomized into three groups receiving (1) no further therapy, (2) BCG, and (3) chemotherapy with biweekly methotrexate and monthly prednisone and vincristine. Children continuing in remission after 8 mo on chemotherapy in group 3 ...

Methotrexate (MTX) is the most widely used drug in cancer chemotherapy and considered to be first-line for treatment of a number rheumatic non-rheumatic disorders. The pulmonary toxicity, hepatotoxicity MTX are two its major side effects. Other toxicities such as endocrinological GI cutaneous hematological fatal malfunction or loss, malignancy can also occur, but at significantly lower rate pre...

PURPOSE Over the past decade, high-dose methotrexate has emerged as the single most effective agent in the initial treatment of primary nervous system lymphoma. However, the majority of patients who respond initially to treatment relapse. The optimal management of these patients has not been determined. We performed a multicenter, retrospective study of high-dose methotrexate in patients with r...

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PURPOSE The RB tumor-suppressor activity may influence the therapeutic response in human breast cancers. The effect of adjuvant therapy on clinical outcome of breast cancer patients was analyzed, and the sensitivity to 5-fluorouracil (5-FU) and methotrexate was investigated in MCF-7 and HCT-116 human cancer cells, according to their RB status. EXPERIMENTAL DESIGN RB protein (pRB) expression w...

High-dose methotrexate is included in chemotherapy regimens used to treat a number of malignant neoplasms. Methotrexate plasma concentration is considered the best toxicity predictor. Monitoring methotrexate plasma concentrations is standard practice in the identification of at-risk patients, the titration of folinic acid doses, and the establishment of corrective measures. Methotrexate is a ki...

The underlying pathophysiology for bone growth defects in paediatric cancer patients receiving high dose methotrexate chemotherapy remains unclear and currently there are no standardized preventative treatments for patients and survivors. Using a model in young rats, we investigated damaging effects of long-term treatment with methotrexate on growth plate and metaphyseal bone, and the potential...