BACKGROUND Stilbenes are 1,2-diphenylethylene congeners produced by plants in response to stress. Many stilbenes also exhibit xenobiotic activities in animal cells, such as inhibition of cancer cell growth, neuroprotection, and immune modulation. In vivo, hydroxylated stilbenes are metabolized by glucuronidation to facilitate excretion. Methoxylated stilbenes are metabolized more slowly, which ...

Methoxylated flavones were recently shown to be promising cancer chemopreventive agents. Their high metabolic stability compared with the hydroxylated analogs was shown in our laboratory using the human hepatic S9 fraction with cofactors for glucuronidation, sulfation, and oxidation. In the present study, the resistance of methoxylated flavones toward oxidative metabolism was investigated with ...

Plants of the genus Piper have long been used as medicinal herbs. The chemistry species has widely investigated and phytochemical investigations conducted in all parts world led to isolation a number physiologically active compounds. Thus, this study was carried out investigate phytochemicals from abbreviatum their acetylcholinesterase inhibitory activity, which not previously investigated. Fra...

Rutin and quercetin absorption and metabolism were investigated in rats after in situ perfusion of jejunum plus ileum (15 nmol/min). In contrast to rutin, a high proportion of quercetin (two-thirds) disappeared during perfusion, reflecting extensive transfer into the intestinal wall. Net quercetin absorption was not complete (2.1 nmol/min), inasmuch as 52% were reexcreted in the lumen as conjug...

Cigarette smoking is a major risk factor in lung carcinogenesis via carcinogens such as polycyclic aromatic hydrocarbons (PAHs) and nitrosamines. In this study, we used benzo[a]pyrene (BaP) as the classic PAH compound and BEAS-2B cells, a model of normal human bronchial epithelial cells, to investigate whether 5,7-dimethoxyflavone (5,7-DMF) and 3',4'-DMF compared with resveratrol (RV) have chem...

Crespy, Vanessa, Christine Morand, Claudine Manach, Catherine Besson, Christian Demigne, and Christian Remesy. Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G120–G126, 1999.—Rutin and quercetin absorption and metabolism were investigated in rats after in situ perfusion of jejun...