The dehalogenation in vivo of brominated aliphatic hydrocarbons such as methyl bromide (1) and bromochloromethane (2) has been demonstrated by recovery of inorganic bromide from blood and urine. The intracellular formation of bromide and methyl alcohol from methyl bromide has been advanced as an explanation for its prolonged toxic effect (3). Evidence for the splitting of chlorinated aliphatic ...

We encountered three patients (Patient I: 39-year-old man, Patient II: 34-year-old woman, and Patient III: 5-year-old girl) with acute methyl bromide poisoning, which had occurred as a result of exposure to the gas that leaked from methyl bromide cans stored in a warehouse of a seedling farm. Since all three patients exhibited almost the same initial symptoms, i.e., severe vomiting, tonic convu...

It was decided at the 4th meeting of the signatories to the “Montreal Protocol Regarding Restriction of Substances Destroying the Ozone Layer” in 1992 to freeze beginning in 1995 the production and consumption of methyl bromide (CH 3 Br), which is mainly used as a plant quarantine fumigant and a soil fumigant, and to totally abolish it by 2005. Methyl bromide has, however, continued to be used ...

Methyl trans-12-octadecenoate-9,10-dz was obtained from methyl threo-12,13-dihydroxy-eis-9-octadecenoate by a sequence of reactions involving formation of an ethoxydioxolane, catalytic deuteration of the double bond, and conversion of the ethoxvdioxolane group to an ethylenic bond. Methyl cisand trans-12-oct;decenoate15,15,16,16-d. and methyl cisand trans-12-octadecenoate-9 ,10,15,15,16,16-d6 w...

BACKGROUND Methyl bromide, a fungicide often used in strawberry cultivation, is of concern for residents who live near agricultural applications because of its toxicity and potential for drift. Little is known about the effects of methyl bromide exposure during pregnancy. OBJECTIVE We investigated the relationship between residential proximity to methyl bromide use and birth outcomes. METHO...

OBJECTIVES To determine the activity of glutathione transferase and to measure the S-methylcysteine adducts in blood proteins, after acute inhalation exposure to methyl bromide. To examine the influence of the polymorphism of glutathione-S-transferase theta (GSTT1) on the neurotoxicity of methyl bromide. METHODS Two workers acutely exposed to methyl bromide with inadequate respiratory protect...