Homochiral (R)- and (S)-3,4-methylenedioxymethamphetamine (MDMA) were prepared in six steps (each) from the chiral pool precursors d- l-alanine, respectively. The key step, copper-catalysed regioselective ring-opening of an N-tosylaziridine with aryl Grignard reagent, proceeded high yield complete regioselectivity. Elaboration was achieved preservation configurational integrity, affording R- S-...

A comparison of the use of aqueous and nonaqueous buffers in association with beta-CD for the chiral separation of (R)- and (S)-3,4-methylenedioxymethamphetamine and related compounds is described. The (R)- and (S)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its major metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared. Under aqueous and nonaqueous buffer conditions and bas...

Ecstasy is a widely used recreational drug that usually consists primarily of 3,4-methylenedioxymethamphetamine (MDMA). Most ecstasy users consume other substances as well, which complicates the interpretation of research in this field. The positively rated effects of MDMA consumption include euphoria, arousal, enhanced mood, increased sociability, and heightened perceptions; some common advers...

The present study strengthens the view that residues of drugs abuse may become widespread surface water contaminants following a local music festival. Overall, 10 illicit were detected from aquatic environment after festival; cocaine and 3,4-methylenedioxymethamphetamine in highest concentrations. presence their metabolites over 3 monitored festival yr suggested consumption these was temporally...