BACKGROUND One lung ventilation (OLV) results in inflammatory and mechanical injury, leading to intraoperative and postoperative complications in children. No interventions have been studied in children to minimize such injury. OBJECTIVE We hypothesized that a single 2-mg·kg(-1) dose of methylprednisolone given 45-60 min prior to lung collapse would minimize injury from OLV and improve physio...

Methylprednisolone is a synthetic glucocorticoid with a potent and long-acting anti-inflammatory, antiallergic and immunosuppressant. Its mechanism of action of methylprednisolone is the result of many cellular changes. Methylprednisolone is used in many diseases, such as rheumatic diseases, autoimmune diseases, allergic, anaphylactic shock, asthma. Methylprednisolone was also used in patients ...

Materials and Methods: Thirty-five adult, albino guinea pigs were randomly divided into 5 groups and were treated as follows: Group (1) received cisplatin alone 13 mg/kg, (2) intratympanic methylprednisolone alone, (3) cisplatin and intratympanic methylprednisolone, (4) intravenous methylprednisolone alone, (5) cisplatin and intravenous methylprednisolone. Baseline and 72 hours post-treatment d...

BACKGROUND Intravenous methylprednisolone hemisuccinate is administered to patients with multiple sclerosis (MS) during exacerbations to improve the rate of recovery. Corticosteroids could be beneficial in MS exacerbations also by decreasing transmigration of peripheral blood mononuclear cells (PBMNCs) through the blood-brain barrier. OBJECTIVES To evaluate how in vivo intravenous methylpredn...