OBJECTIVES One of the irritating features of migraine is emesis that can compromise taking oral medications. We designed this study to compare the effectiveness of granisetron and metoclopramide in reducing pain and treating emesis in migraine patients. METHODS We included a total of 148 patients with migraine headache presenting to two referral hospitals in a prospective, double-blinded rand...

conclusions dexamethasone 8mg is a better anti-emetic agent than metoclopramide for the prevention of post-operative nausea and vomiting after laparoscopic cholecystectomy. objectives this study evaluates the prophylactic anti-emetic effect of dexamethasone in comparison with metoclopramide and placebo for the prevention of post-operative nausea and vomiting in patients undergoing elective lapa...

Background: Exclusive breastfeeding is beneficial to not only infants, but also mothers. Since prolactin stimulates milk production, increasing its levels through dopamine antagonists, such as metoclopramide, may enhance milk production. However, the efficacy of this method should be further studied. Therefore, this systematic review sought to determine the effects of metoclopramide on prolacti...

effect of helicobacter pylori eradication or of ranitidine plus metoclopramide on helicobacter pylori-positive and of bismuth or ranitidine plus metoclopramide on helicobacter pylori-negative functional dyspepsia. a  randomized, controlled follow-up study.

A 54-year-old Japanese woman was diagnosed with major depressive disorder and prescribed paroxetine 20 mg/day. In around May 2013, the patient experienced gastric discomfort, so metoclopramide was prescribed. Beginning on June 4, 2013, the patient was given metoclopramide, 10 mg intravenously, twice per week. On the seventh day after beginning metoclopramide, facial hot flushes, increased sweat...

A randomised double-blind crossover study was undertaken to compare the anti-emetic efficacy of alizapride against high dose metoclopramide. A total of 32 patients on cisplatin were randomised to receive either high dose metoclopramide (7 mg kg-1 day-1) or alizapride (5 mg kg-1 day-1). Anti-emetic responses in terms of control of vomiting episodes were similar in both regimens (59%). However, p...

BACKGROUND/AIM Metoclopramide is an effective and commonly used medication in acute migraine treatment but an experimental evidence base is lacking. We aimed to investigate the antimigraine effect of metoclopramide in a migraine model and whether the analgesic effect of metoclopramide was likely to be D2 receptor-mediated. MATERIALS AND METHODS Cortical spreading depression (CSD) was used to ...

Purpose. Study the radiolysis of solid-state metoclopramide hydrochloride at various absorbed doses. Elucidate the structure of the degradation products to gain information on the radiolysis mechanisms. Methods. Solid-state metoclopramide samples were irradiated at several doses with gamma rays and highenergy electrons to evaluate the influence of the dose rate. High-performance liquid chromato...

Objective: This prospective, randomized, double-blind study was performed to evaluate the effects of intravenous co-administration of metoclopramide and ranitidine on preoperative gastric contents in patients receiving general anesthesia for elective laparoscopic cholecystectomy surgery, a procedure with high risk of aspiration. Material and Methods: Eighty ASA physical status I-II consenting p...

Two of 7 patients with acromegaly and one of 7 normal subjects exhibited a paradoxical rise in growth hormone (GH) to human corticotropin-releasing hormone (CRH) when pretreated with metoclopramide, although CRH alone did not induce an increase in GH. In one of these two patients with acromegaly, the GH increase to metoclopramide alone also reached the criteria of a paradoxical response. These ...