Lax, Antonio, Fernando Soler, and Francisco Fernandez-Belda. Inhibition of sarcoplasmic reticulum Ca2 ATPase by miconazole. Am J Physiol Cell Physiol 283: C85–C92, 2002. First published February 20, 2002; 10.1152/ ajpcell.00580.2001.—The inhibition of sarcoplasmic reticulum Ca2 -ATPase activity by miconazole was dependent on the concentration of ATP and membrane protein. Half-maximal inhibition...

BACKGROUND AND OBJECTIVE Miconazole is a broad-spectrum antifungal drug that has poor aqueous solubility (<1 µg/mL); as a result, a reduction in its therapeutic efficacy has been reported. The aim of this study was to formulate and evaluate miconazole-loaded solid lipid nanoparticles (MN-SLNs) for oral administration to find an innovative way to alleviate the disadvantages associated with comme...

OBJECTIVE To examine the extra cost of using higher-priced drugs as initial therapy for dermatophyte infections, because the many available effective drugs vary considerably in cost. DESIGN Cost analysis from the purchaser's perspective, comparing two prototypical regimens to treat tinea pedis: one in which all patients initially receive a lower-priced drug and those with unresponsive infecti...

Six domestic African pygmy hedgehogs (Atelerix albiventris) were treated for Otodectes cynotis infestation. Symptoms included skin lesions, itching, and slight lethargy. The given a bath with shampoo containing miconazole chlorhexidine, selamectin solution was applied to the in between spines. Skin scraping negative mite infestation after 15 days of treatment, inflammation, swelling decreased s...

An innovative, simple, economic, selective and sensitive of the stability indicating gradient reverse phase high performance liquid chromatography (RP-HPLC) method has been developed and validated for the analysis of assay of Miconazole nitrate and Benzoic acid and related substances of Miconazole nitrate in gel dosage form with better precision and accuracy. Miconazole nitrate & Benzioc acid a...

A novel compounding vehicle (RECURA) has previously been proven to penetrate the nail bed when compounded with the antifungal agent miconazole or fluconazole, providing for an effective treatment for onychomycosis. In this study, miconazole and fluconazole were compounded separately in RECURA compounding cream, and they were tested at different time points (0, 7, 14, 28, 45, 60, 90, and 180 day...

In a multicenter, randomized, invesgtigator-blind, parallel study, 398 patients were dispensed topical butoconazole nitrate 2% cream for 3 days (n = 199) or miconazole nitrate 2% cream for 7 days (n = 199) for vaginal use. Efficacy analyses included 254 patients with culture-confirmed Candida (119 butoconazole and 135 miconazole users). Of the 398 patients issued study medication, 9 were lost t...

The use of hot-melt extrusion for preparing homogeneous API-excipient mixtures is studied for miconazole-PEG-g-PVA [poly(ethylene glycol)-poly(vinyl alcohol) graft copolymer] solid dispersions with a 5 cm(3) table-top, twin-screw corotating microcompounder (DSM Xplore). Phase behavior of PEG-g-PVA, miscibility of miconazole in PEG-g-PVA and the partitioning of miconazole between PEG and PVA amo...

The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means of predicting potential drug-drug interactions, have not yet been investigated. The objective of this study was to evaluate the specificity and selectivity of five antifungal agents using selective probe reactions for each of the eight major P450s. The index reactions used were phenacetin O-deethylation (...