Purpose: Miconazole nitrate is a widely used antifungal agent but its use in topical formulation is not efficacious because deep ereated fungal infections are difficult to treat with conventional topical formulation. The purpose of this study was to prepare miconazole incorporated different novel carriers such as liposomes, ethosomes and to compare their in vitro skin permeation studies with pl...

In an effort to increase the efficacy of topical medications for treating onychomycosis, several new nail penetration enhancers were recently developed. In this study, the ability of 10% (wt/wt) miconazole nitrate combined with a penetration enhancer formulation to permeate the nail is demonstrated by the use of a selection of in vitro nail penetration assays. These assays included the bovine h...

In a prospective study, 100 women with recurrent vaginal candidosis were treated with miconazole, using two 100 mg vaginal pessaries a day for one week, then one pessary twice a week for three months followed by one pessary a week for a further three months. Fifty four women elected to continue using one pessary a week for longer than six months. Symptomatic vaginal candidosis did not occur in ...

Miconazole is a Biopharmaceutics Classification System (BCS) class II drug, thus limiting its oral bioavailability. Nanosponges can improve the bioavailability of poorly soluble drugs and sustain their release. The work was aimed at formulating miconazole nanosponges to enhance solubility consequently, Batches incorporating different concentrations (1, 2 3 %) nitrate were formed using ethyl cel...

In the title compound, C(20)H(21)N(2)O(2)S(+)·NO(3) (-), the dihedral angle between the pyridinium and phenyl rings is 81.77 (19)°, that between the pyridinium and tolyl rings is 1.36 (18)°, and that between the phenyl and tolyl rings is 82.69 (19)°. In the crystal, the components are linked by strong charge-assisted bifurcated N(+)-H⋯(O,O) hydrogen bonds and the packing is consolidated by nume...

The asymmetric unit of the title compound, [Ag(C(9)H(8)N(2))(2)]NO(3), contains one complete [Ag(C(9)H(8)N(2))(2)](+) cation and two half-cations (with the other halves generated through inversion) and two NO(3) (-) anions. Each Ag(I) ion shows a linear AgN(2) coordination. The ions are linked by N-H⋯O hydrogen bonds.

The title compound, [Co(NH(3))(6)](2)Cl(5)(NO(3)), was obtained under hydro-thermal conditions. The asymmetric unit contains three Co(3+) ions, one lying on an inversion center and the other two located at 2/m positions. All Co(3+) ions are six-coordinated by NH(3) mol-ecules, forming [Co(NH(3))(6)](3+) octahedra, with Co-N distances in the range 1.945 (4)-1.967 (3) Å. The nitrate N atom and on...