Ketorolac tromethamine (KT) containing microemulsion-based gels (MBGs) have been formulated, based on the previous phase diagram studies, using a pharmaceutically acceptable surfactant (soybean lecithin; Epikuron 200) and oil (isopropyl myristate; IPM) and the effect of formulation variables on the release profile of the drug from MBGs through intact guinea pig skin and various artificial membr...

We present an innovative methodology for the sustained delivery of hydrophobic drugs using composite hydrogels, prepared by embedding oil-in-water microemulsions in hydrophilic hydrogels. The hydrophobic nature of the microemulsion core enhances the solubilization of hydrophobic drugs, while the crosslinked matrix could be readily used as a solid controlled delivery vehicle. A microemulsion was...

Ketorolac tromethamine (KT) containing microemulsion-based gels (MBGs) have been formulated, based on the previous phase diagram studies, using a pharmaceutically acceptable surfactant (soybean lecithin; Epikuron 200) and oil (isopropyl myristate; IPM) and the effect of formulation variables on the release profile of the drug from MBGs through intact guinea pig skin and various artificial membr...

Small-angle neutron scattering and turbidity were used to probe nanoscale structure in bicontinuous microemulsions before and after polymerization. Difficulties in capturing nanoscale structure by polymerizing microemulsions have persisted with the use of thermal initiation. Bicontinuous microemulsion polymerization with a reactive surfactant monomer and cross-linker was done with only a 20% in...

The objective of the present investigation was to develop and evaluate microemulsion based gel for the vaginal delivery of Sertaconazole. The solubility of Sertaconazole in various oils, surfactants and co-surfactants were checked to identify components of the microemulsion. The ternary diagrams were plotted to identify the area of microemulsion existence. Various gelling agents were evaluated ...

BACKGROUND Rotigotine is a potent and selective D1, D2, and D3 dopaminergic receptor agonist. Due to an extensive first-pass effect, it has a very low oral bioavailability (approximately 0.5% in rats). PURPOSE The present investigation aimed to develop a microemulsion-based hydrogel for transdermal rotigotine delivery with lower application site reactions. METHODS Pseudoternary phase diagra...

The Essential oil (EO) of Nigella sativa (black cumin) was extracted from the crude oil and the volatile constituents were characterized using gas chromatographic analysis. The EO was formulated in water-based microemulsion system and its antibacterial activity against six pathogenic bacteria was evaluated using the agar well diffusion method. This activity was compared with two other well know...