In the present study, the micronucleus test was applied in exfoliated cells of buccal mucosa to assess the mutagenicity risk associated with occupational exposure for gas station attendants. For each individual, 2000 exfoliated buccal cells were analyzed for micronucleus frequency. A highly significant difference was found between exposed and control groups. Likewise, a significant difference w...

The lymphocyte micronucleus assay was used to measure the average frequency of micronuclei in a population and thus assess genotoxic effects. Data from 174 persons give an average value of 16.4 +/- 7.3, and a slight age-dependence was observed. To detect combined environmental mutagen injuries the micronucleus assay was used to study the effects of metal compounds. Cadmium ions increased the mi...

The genotoxic effect of the Austroplenckia populnea chloroform fraction from barkwood extract was tested in vivo on peripheral blood cells of Swiss mice with the comet assay (SCGE), and the clastogenic effect was investigated on peripheral blood cells of Swiss mice and bone marrow cells of Wistar rats, with the micronucleus and chromosome aberrations tests. The animals were treated by gavage wi...

OBJECTIVES The aim of this study was to investigate the genotoxic effects of indium trichloride (InCl(3)·4H(2)O; InCl(3)) using the in vivo bone marrow micronucleus test and the in vitro CHL/IU cell micronucleus test. METHOD BALB/c mice were administered a single intraperitoneal (i.p.) injection of InCl (3) at a dose 0.625, 1.25, 2.5, 5, or 10 mg/kg b.w. The frequency of micronuclei, the rati...

Aim: Fish are the object of study to detect potential contaminants, Mutagenic or carcinogenic present in the water. Besides fish toxicant similar response can provide higher vertebrates for chemicals that are carcinogenic to humans. Micronucleus test (MNT) is a technique developed by Schmid (1975), using the cells as an object of study, and by treating with chemicals as a genotoxic test. Micron...

Background and aim: Increased rate of micronucleus in buccal mucosa cells and its correlation with carcinogenesis is worth consideration. Recently, occupation in dental laboratories has been proposed as a predisposing factor. Therefore, the present study aimed to evaluate the effect of occupational exposure on buccal mucosa cells of dental laboratory technicians. Materials and methods: This ...